A short and efficient asymmetric synthesis of komaroviquinone

被引：19
|
作者：
Suto, Yutaka [1 ]
Kaneko, Kento [1 ]
Yamagiwa, Noriyuki [1 ]
Iwasaki, Genji [1 ]
机构：
[1] Takasaki Univ Hlth & Welf, Fac Pharm, Gunma 3700033, Japan
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 48期
关键词：
TRYPANOSOMA-CRUZI; DRUGS;
D O I：
10.1016/j.tetlet.2010.09.110
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An asymmetric total synthesis of komaroviquinone (1), which is a natural product isolated from Draco-cephalum komarovi and shows novel potent trypanocidal activity, was achieved in five steps from the known starting materials. The synthetic route is shorter and more efficient than the reported methods and also useful for the scale-up synthesis. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：6329 / 6330
页数：2
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