Inverse correlation between longevity and developmental rate among wild C-elegans strains

被引：16

作者：

Lee, Yujin ^{[1
]}

Hwang, Wooseon ^{[1
]}

Jung, Juyoung ^{[1
]}

Park, Sangsoon ^{[1
]}

Cabatbat, Josephine Jill T. ^{[4
]}

Kim, Pan-Jun ^{[4
,5
]}

Lee, Seung-Jae V. ^{[1
,2
,3
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Life Sci, Pohang, Gyeongbuk, South Korea

[2] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang, Gyeongbuk, South Korea

[3] Pohang Univ Sci & Technol, Informat Technol Convergence Engn, Pohang, Gyeongbuk, South Korea

[4] Asia Pacific Ctr Theoret Phys, Pohang, Gyeongbuk, South Korea

[5] Pohang Univ Sci & Technol, Dept Phys, Pohang, Gyeongbuk, South Korea

来源：

AGING-US | 2016年 / 8卷 / 05期

关键词：

aging; lifespan; fitness; development; reproduction; C; elegans; CAENORHABDITIS-ELEGANS; LIFE-SPAN; NATURAL VARIATION; GENETIC-ANALYSIS; EVOLUTION; POLYMORPHISM; MTOR; GEROCONVERSION; POPULATIONS; SENESCENCE;

D O I：

10.18632/aging.100960

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness in wild organisms remains inconclusive. Here, we determined the correlation between lifespan and fitness, developmental rate and brood size, by using 16 wild-derived C. elegans strains originated from various geographic areas. We found a negative correlation between lifespan and developmental rate. In contrast, we did not find such negative correlation between longevity and developmental rate among the individuals of C. elegans strains. These data imply that polymorphic genetic variants among wild isolates determine resource allocation to longevity and developmental rate.

引用

页码：986 / 999

页数：14

共 50 条

[41] Uncoupling of longevity and telomere length in C-elegans (vol 1, pg 295, 2005)
Raices, M
Maruyama, H
Dillin, A
Karlseder, J
PLOS GENETICS, 2005, 1 (06): : 748 - 748
[42] Environmental Temperature Differentially Modulates C-elegans Longevity through a Thermosensitive TRP Channel
Zhang, Bi
Xiao, Rui
Ronan, Elizabeth A.
He, Yongqun
Hsu, Ao-Lin
Liu, Jianfeng
Xu, X. Z. Shawn
CELL REPORTS, 2015, 11 (09): : 1414 - 1424
[43] Regulation of longevity in C-elegans by stress- and aging-associated proteins in vitro
Chung, K
Liu, H
Ha, M
Bang, D
Park, Y
Lee, K
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 124 (04) : A3 - A3
[44] Multiparameter evaluation of the longevity in C-elegans under stress using an integrated microfluidic device
Wen, Hui
Shi, Weiwei
Qin, Jianhua
BIOMEDICAL MICRODEVICES, 2012, 14 (04) : 721 - 728
[45] The C-elegans TGF-β dauer pathway regulates longevity via insulin signaling
Shaw, Wendy M.
Luo, Shijing
Landis, Jessica
Ashraf, Jasmine
Murphy, Coleen T.
CURRENT BIOLOGY, 2007, 17 (19) : 1635 - 1645
[46] Steroid Regulation of C. elegans Diapause, Developmental Timing, and Longevity
Antebi, Adam
DEVELOPMENTAL TIMING, 2013, 105 : 181 - 212
[47] FTIR imaging detects diet and genotype-dependent chemical composition changes in wild type and mutant C-elegans strains
Bouyanfif, A.
Liyanage, S.
Hewitt, J. E.
Vanapalli, S. A.
Moustaid-Moussa, N.
Hequet, E.
Abidi, N.
ANALYST, 2017, 142 (24) : 4727 - 4736
[48] The centrosome of the early C-elegans embryo:: Inheritance, assembly, replication, and developmental roles
O'Connell, KF
CENTROSOME IN CELL REPLICATION AND EARLY DEVELOPMENT, 2000, 49 : 365 - 384
[49] Germline and developmental roles of the nuclear transport factor importin α3 in C-elegans
Geles, KG
Adam, SA
DEVELOPMENT, 2001, 128 (10): : 1817 - 1829
[50] UNC-13 expression in wild-type and mutant C-elegans
Duerr, JS
Eustance, RJ
Duke, AL
Rand, JB
MOLECULAR BIOLOGY OF THE CELL, 1996, 7 : 3563 - 3563

← 1 2 3 4 5 →