Inverse correlation between longevity and developmental rate among wild C-elegans strains

被引：15
|
作者：
Lee, Yujin [1 ]
Hwang, Wooseon [1 ]
Jung, Juyoung [1 ]
Park, Sangsoon [1 ]
Cabatbat, Josephine Jill T. [4 ]
Kim, Pan-Jun [4 ,5 ]
Lee, Seung-Jae V. [1 ,2 ,3 ]
机构：
[1] Pohang Univ Sci & Technol, Dept Life Sci, Pohang, Gyeongbuk, South Korea
[2] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang, Gyeongbuk, South Korea
[3] Pohang Univ Sci & Technol, Informat Technol Convergence Engn, Pohang, Gyeongbuk, South Korea
[4] Asia Pacific Ctr Theoret Phys, Pohang, Gyeongbuk, South Korea
[5] Pohang Univ Sci & Technol, Dept Phys, Pohang, Gyeongbuk, South Korea
来源：
AGING-US | 2016年 / 8卷 / 05期
关键词：
aging; lifespan; fitness; development; reproduction; C; elegans; CAENORHABDITIS-ELEGANS; LIFE-SPAN; NATURAL VARIATION; GENETIC-ANALYSIS; EVOLUTION; POLYMORPHISM; MTOR; GEROCONVERSION; POPULATIONS; SENESCENCE;
D O I：
10.18632/aging.100960
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness in wild organisms remains inconclusive. Here, we determined the correlation between lifespan and fitness, developmental rate and brood size, by using 16 wild-derived C. elegans strains originated from various geographic areas. We found a negative correlation between lifespan and developmental rate. In contrast, we did not find such negative correlation between longevity and developmental rate among the individuals of C. elegans strains. These data imply that polymorphic genetic variants among wild isolates determine resource allocation to longevity and developmental rate.
引用
收藏
页码：986 / 999
页数：14
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