The effect of the Monocyte Locomotion Inhibitory Factor (MLIF) produced by entamoeba histolytica upon ThI/Th2 cytokines expression by T CD4+ lymphocytes

被引：0

作者：

Rojas, S ^{[1
]}

Rico, G ^{[1
]}

Valázquez, J ^{[1
]}

Pérez, J ^{[1
]}

Kretschmer, I ^{[1
]}

机构：

[1] Hosp Pediat Mexico City, Ctr Med Nacl Siglo 21, IMSS, Unidad Invest Med & Inmunol, Mexico City, DF, Mexico

来源：

IMMUNOLOGY 2004: IMMUNODEFICIENCY, INFECTIOUS DISEASES, IMMUNOMODULATION, AND VACCINES | 2004年

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

E. histolytica produced an unusual inflammatory reaction with acute phase yet, but only a very weak late can be found. E. histolytica produces Monocyte Locomotion Inhibitory Factor (MLIF), a pentapeptide, with in vitro and in vivo anti-inflammatory properties. The MLIF may interfere with leukocyte migration disturbing the balance of cytokines secreted by Th1/Th2 lymphocytes. We evaluated the effect of MLIF on activation and production of Th1/Th2 cytokines in human T CD4+ lymphocytes. Expression of CD69 was determined by flow cytometry and Th1/Th2 regulation was studied by intracellular cytokines collocated with chemokine receptors. MLIF activated T CD4+ lymphocytes and induced Th1/Th2 cytokine expression as PMA.

引用

页码：223 / 228

页数：6

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