The dealkylation of tertiary aliphatic amines with phenyl chlorothionoformate

被引：19
|
作者：
Millan, DS [1 ]
Prager, RH [1 ]
机构：
[1] Flinders Univ S Australia, Dept Chem, Adelaide, SA 5001, Australia
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 24期
关键词：
D O I：
10.1016/S0040-4039(98)00743-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Phenyl chlorothionoformate reacts rapidly with aliphatic amines at 20 degrees C to give a thiourethane and an alkyl chloride. The urethanes are readily converted to the secondary amine salt by reaction with dimethyl sulfate, followed by hydrolysis with water. Rates of reaction, and alkyl group cleavage selectivity, are comparable to those reported for 1-chloroethyl chloroformate. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4387 / 4390
页数：4
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