Mild water-promoted selective deacetalisatison of acyclic acetals

被引:28
|
作者
Williams, D. Bradley G. [1 ]
Cullen, Adam [1 ]
Fourie, Alex [1 ]
Henning, Hendrik [1 ]
Lawton, Michelle [1 ]
Mommsen, Wayne [1 ]
Nangu, Portia [1 ]
Parker, Jonathan [1 ]
Renison, Alicia [1 ]
机构
[1] Univ Johannesburg, Dept Chem, Res Ctr Synth & Catalysis, ZA-2006 Auckland Pk, South Africa
关键词
HYDROLYSIS; CATALYST; ACID;
D O I
10.1039/c0gc00280a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Various aliphatic and aromatic dimethyl and diethyl acetals and ketals were found to hydrolyse in essentially quantitative yield when heated to 80 degrees C in neat water or aqueous medium without a catalyst or any other additive, while cyclic acetals were stable under these conditions. Selective deprotection is possible when both types of acetal are present.
引用
收藏
页码:1919 / 1921
页数:3
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