The role of the oral environment in HIV-1 transmission

被引：71
|
作者：
Shugars, DC
Wahl, SM
机构：
[1] Univ N Carolina, Sch Dent, Dept Dent Ecol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Med, Dept Immunol & Microbiol, Chapel Hill, NC 27599 USA
[3] NIDR, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION | 1998年 / 129卷 / 07期
关键词：
D O I：
10.14219/jada.archive.1998.0349
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Human immunodeficiency virus type 1, or HIV-1, is infrequently transmitted through the mouth, unlike other mucosal sites. Factors such as low salivary viral titers, low numbers of CD4-positive target cells, anti-HIV antibodies and endogenous salivary antiviral factors work in concert to protect oral tissues from Infection and reduce the risk of viral transmission through salivary secretions. This review summarizes the various factors thought to influence oral transmission of HIV-1, focusing on the mucosal protein secretory leukocyte protease inhibitor, or SLPI.
引用
收藏
页码：851 / 858
页数：8
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