Severe Eosinophilia in an Infant With Congenital Acute Myeloid Leukemia With t(3;4;6)(q26;q25;q21): A Case Report

被引：3

作者：

Harisi, Marieta ^{[2
]}

Douna, Varvara ^{[2
]}

Baka, Margarita ^{[1
]}

Servitzoglou, Marina ^{[1
]}

Kosmidi, Helen ^{[1
]}

Anastasiou, Theodora ^{[2
]}

机构：

[1] PA Kyriakou Childrens Hosp, Pediat Hematol Oncol Dept, Athens 11527, Greece

[2] PA Kyriakou Childrens Hosp, Hematol Lab, Athens 11527, Greece

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2010年 / 32卷 / 06期

关键词：

acute megakaryoblastic leukemia; congenital leukemia; eosinophilia; ACUTE MEGAKARYOBLASTIC LEUKEMIA; ONCOLOGY-GROUP; CHILDHOOD; EXPERIENCE; CYTOGENETICS;

D O I：

10.1097/MPH.0b013e3181e40e1b

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case of acute myeloid leukemia with morphologic features of M7 according to the FAB (French-American-British) classification and severe eosinophilia in the peripheral blood and bone marrow at diagnosis. We consider it as congenital leukemia, as the symptoms started in the first month of life of the affected child. This case of leukemia is characterized by t(3;4;6)(q26;q25;q21) cytogenetic abnormality. The blasts in flow cytometry analysis expressed markers of megakaryocytic lineage along with expression of myeloperoxidase in 30% of them. This type of acute myelogenous leukemia with severe eosinophilia can be considered as a distinct clinicopatologic entity.

引用

页码：497 / 500

页数：4

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