Severe Eosinophilia in an Infant With Congenital Acute Myeloid Leukemia With t(3;4;6)(q26;q25;q21): A Case Report

被引：3
|
作者：
Harisi, Marieta [2 ]
Douna, Varvara [2 ]
Baka, Margarita [1 ]
Servitzoglou, Marina [1 ]
Kosmidi, Helen [1 ]
Anastasiou, Theodora [2 ]
机构：
[1] PA Kyriakou Childrens Hosp, Pediat Hematol Oncol Dept, Athens 11527, Greece
[2] PA Kyriakou Childrens Hosp, Hematol Lab, Athens 11527, Greece
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2010年 / 32卷 / 06期
关键词：
acute megakaryoblastic leukemia; congenital leukemia; eosinophilia; ACUTE MEGAKARYOBLASTIC LEUKEMIA; ONCOLOGY-GROUP; CHILDHOOD; EXPERIENCE; CYTOGENETICS;
D O I：
10.1097/MPH.0b013e3181e40e1b
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a case of acute myeloid leukemia with morphologic features of M7 according to the FAB (French-American-British) classification and severe eosinophilia in the peripheral blood and bone marrow at diagnosis. We consider it as congenital leukemia, as the symptoms started in the first month of life of the affected child. This case of leukemia is characterized by t(3;4;6)(q26;q25;q21) cytogenetic abnormality. The blasts in flow cytometry analysis expressed markers of megakaryocytic lineage along with expression of myeloperoxidase in 30% of them. This type of acute myelogenous leukemia with severe eosinophilia can be considered as a distinct clinicopatologic entity.
引用
收藏
页码：497 / 500
页数：4
相关论文
共 50 条
  • [1] Allogeneic Stem Cell Transplantation for t(3;3)(q21;q26)/Inv(3)(q21;q26) Acute Myeloid Leukemia - Report from the Acute Leukemia Working Party of the EBMT
    Halaburda, Kazimierz
    Labopin, Myriam
    Houhou, Mohamed
    Niederwieser, Dietger
    Finke, Juergen
    Volin, Liisa
    Maertens, Johan A.
    Comelissen, Jan
    Milpied, Noel
    Stuhler, Gernot
    Kroeger, Nicolaus
    Esteve, Jordi
    Mohty, Mohamad
    Nagler, Arnon
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2016, 22 (03) : S34 - S34
  • [2] Allogeneic Stem Cell Transplantation for t(3;3)(q21;q26)/inv(3)(q21;q26) Acute Myeloid Leukemia - Report from the Acute Leukemia Working Party of the EBMT
    Halaburda, K.
    Labopin, M.
    Houhou, M.
    Niederwieser, D.
    Finke, J.
    Violin, L.
    Maertens, J.
    Cornelissen, J. J.
    Milpied, N.
    Stuhler, G.
    Kroeger, N.
    Esteve, J.
    Mohty, M.
    Nagler, A.
    BONE MARROW TRANSPLANTATION, 2016, 51 : S283 - S284
  • [3] Is there a role for allogeneic stem cell transplantation for t(3;3) (q21;q26)/inv(3) (q21;q26) acute myeloid leukemia? A report from the ALWP of the EBMT
    Halaburda, K.
    Labopin, M.
    Esteeve, J.
    Mohty, M.
    Nagler, A.
    BONE MARROW TRANSPLANTATION, 2017, 52 : S116 - S117
  • [4] THE CASE REPORT OF CHRONIC MYELOID LEUKEMIA WITH RARE SECONDARY TRANSLOCATION T(3;7)(Q26;Q21)
    Karimov, H. Ya
    Assesorova, Yu. Yu
    Kazakbaeva, H. M.
    GEMATOLOGIYA I TRANSFUZIOLOGIYA, 2017, 62 (02): : 101 - 104
  • [5] CHARACTERIZATION OF THE RARE TRANSLOCATION T(3;10)(Q26;Q21) IN AN ACUTE MYELOID LEUKEMIA PATIENT
    Jancuskova, T.
    Plachy, R.
    Stika, J.
    Hardekopf, D. W.
    Zejskova, L.
    Praulich, I.
    Kreuzer, K. A.
    Kosyakova, N.
    Liehr, T.
    Pekova, S.
    HAEMATOLOGICA, 2014, 99 : 283 - 284
  • [6] Translocation t(1;10)(q21;q26) in a case of acute nonlymphocytic leukemia
    Terreros, MC
    Quesada, M
    Slavutsky, IR
    ACTA HAEMATOLOGICA, 1998, 99 (02) : 92 - 94
  • [7] AlloHSCT for inv(3)(q21;q26)/t(3;3)(q21;q26) AML: a report from the acute leukemia working party of the European society for blood and marrow transplantation
    Kazimierz Halaburda
    Myriam Labopin
    Mohamed Houhou
    Dietger Niederwieser
    Jürgen Finke
    Liisa Volin
    Johan Maertens
    Jan J. Cornelissen
    Noel Milpied
    Gernot Stuhler
    Nicolaus Kröger
    Jordi Esteve
    Mohamad Mohty
    Arnon Nagler
    Bone Marrow Transplantation, 2018, 53 : 683 - 691
  • [8] AlloHSCT for inv(3)(q21;q26)/t(3;3)(q21;q26) AML: a report from the acute leukemia working party of the European society for blood and marrow transplantation
    Halaburda, Kazimierz
    Labopin, Myriam
    Houhou, Mohamed
    Niederwieser, Dietger
    Finke, Juergen
    Volin, Liisa
    Maertens, Johan
    Cornelissen, Jan J.
    Milpied, Noel
    Stuhler, Gernot
    Kroeger, Nicolaus
    Esteve, Jordi
    Mohty, Mohamad
    Nagler, Arnon
    BONE MARROW TRANSPLANTATION, 2018, 53 (06) : 683 - 691
  • [9] Molecular and Clinical Aspects of Acute Myeloid Leukemia with Inv(3)(q21q26)/t(3;3)(q21;q26) Carrying Spliceosomal Mutations
    Awada, Hassan
    Kerr, Cassandra M.
    Rogers, Heesun J.
    Maciejewski, Jaroslaw P.
    Visconte, Valeria
    BLOOD, 2020, 136
  • [10] Molecular characterization of the rare translocation t(3;10)(q26;q21) in an acute myeloid leukemia patient
    Tereza Jancuskova
    Radek Plachy
    Lucie Zemankova
    David Warren Hardekopf
    Jiri Stika
    Lenka Zejskova
    Inka Praulich
    Karl-Anton Kreuzer
    Achim Rothe
    Moneeb AK Othman
    Nadezda Kosyakova
    Sona Pekova
    Molecular Cytogenetics, 7
12345