Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission

被引：98
|
作者：
de Witte, Lot [1 ]
Nabatov, Alexey [1 ]
Geijtenbeek, Teunis B. H. [1 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands
来源：
TRENDS IN MOLECULAR MEDICINE | 2008年 / 14卷 / 01期
关键词：
D O I：
10.1016/j.molmed.2007.11.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present., the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission.
引用
收藏
页码：12 / 19
页数：8
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