The effects of a high eicosapentaenoic acid multinutrient supplement on measures of stress, anxiety and depression in young adults: Study protocol for NutriMOOD, a randomised double-blind placebo-controlled trial

被引:1
|
作者
Kelaiditis, Christos F. [1 ]
Gibson, E. Leigh [2 ]
Dyall, Simon C. [1 ]
机构
[1] Univ Roehampton, Sch Life & Hlth Sci, Holybourne Ave, London SW15 4JD, England
[2] Univ Roehampton, Sch Psychol, London, England
关键词
Anxiety; Depression; Stress; Eicosapentaenoic acid; Docosahexaenoic acid; POLYUNSATURATED FATTY-ACIDS; UNIVERSITY-STUDENTS; GENETIC-VARIANTS; OMEGA-3-FATTY-ACIDS; VALIDATION; QUESTIONNAIRE; COMORBIDITY; DISORDERS; MOBILITY; CLUSTER;
D O I
10.1016/j.plefa.2021.102335
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Anxiety disorders affect nearly 20% of young adults aged 18-29 years. First-line treatment for anxiety disorders comprises pharmacotherapy and Cognitive Behavioural Therapy, options often criticised for their low efficacy and safety. In contrast, fish-oil-based supplements comprising omega-3 polyunsaturated fatty acids and supporting nutrients are gaining recognition as safe and effective alternatives. Here we present the protocol for a randomised, double-blind, placebo-controlled trial investigating the effects of a high eicosapentaenoic acid multinutrient supplement on validated measures of anxiety and depression in healthy university students experiencing non-clinical levels of anxiety and depression. The primary outcome is improvement in anxiety compared to the placebo group assessed via the Generalised Anxiety Disorder Assessment-7 scale. The participants will be randomised to active treatment comprising a daily dose of 1125 mg eicosapentaenoic acid, 441 mg docosahexaenoic acid, 330 mg magnesium and 7.5 mg vitamin E, or placebo, for 24 weeks, and will complete validated questionnaires and tablet-based tasks sensitive to mood at baseline and end of intervention. Circulating fatty acids and key biomarkers will also be assessed. The students will be genotyped for polymorphisms thought to influence the relationship between long-chain omega-3 polyunsaturated fatty acids and affect. Trial registration; ClinicalTrials.gov, NCT04844034.
引用
收藏
页数:8
相关论文
共 50 条
  • [1] Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study
    Frangou, S
    Lewis, M
    McCrone, P
    BRITISH JOURNAL OF PSYCHIATRY, 2006, 188 : 46 - 50
  • [2] Sertraline for anxiety in adults with a diagnosis of autism (STRATA): study protocol for a pragmatic, multicentre, double-blind, placebo-controlled randomised controlled trial
    Rai, Dheeraj
    Webb, Doug
    Lewis, Amanda
    Cotton, Leonora
    Norris, Jade Eloise
    Alexander, Regi
    Baldwin, David S.
    Brugha, Traolach
    Cochrane, Madeleine
    Del Piccolo, Maria Chiara
    Glasson, Emma J.
    Hatch, Katherine K.
    Kessler, David
    Langdon, Peter E.
    Leonard, Helen
    Macneill, Stephanie J.
    Mills, Nicola
    Morales, Maximiliano Vazquez
    Morgan, Zoe
    Mukherjee, Raja
    Realpe, Alba X.
    Russell, Ailsa
    Starkstein, Sergio
    Taylor, Jodi
    Turner, Nicholas
    Thorn, Joanna
    Welch, Jack
    Douglas, Sarah
    Hale, Peter
    O'Brien, Sarah
    Walker, Amy
    Wiles, Nicola
    TRIALS, 2024, 25 (01)
  • [3] Sertraline for anxiety in adults with a diagnosis of autism (STRATA): study protocol for a pragmatic, multicentre, double-blind, placebo-controlled randomised controlled trial
    Dheeraj Rai
    Doug Webb
    Amanda Lewis
    Leonora Cotton
    Jade Eloise Norris
    Regi Alexander
    David S. Baldwin
    Traolach Brugha
    Madeleine Cochrane
    Maria Chiara Del Piccolo
    Emma J. Glasson
    Katherine K. Hatch
    David Kessler
    Peter E. Langdon
    Helen Leonard
    Stephanie J. MacNeill
    Nicola Mills
    Maximiliano Vazquez Morales
    Zoe Morgan
    Raja Mukherjee
    Alba X. Realpe
    Ailsa Russell
    Sergio Starkstein
    Jodi Taylor
    Nicholas Turner
    Joanna Thorn
    Jack Welch
    Nicola Wiles
    Trials, 25
  • [4] Effects of 12 weeks colostrum milk supplement among older adults: A randomised, double-blind and placebo-controlled trial
    Ooi, Theng Choon
    Ahmad, Azizan
    Rajab, Nor Fadilah
    Sharif, Razinah
    INTERNATIONAL DAIRY JOURNAL, 2024, 149
  • [5] The Effects of Probiotics on Symptoms of Depression: Protocol for a Double-Blind Randomized Placebo-Controlled Trial
    Wallace, Caroline J. K.
    Foster, Jane A.
    Soares, Claudio N.
    Milev, Roumen, V
    NEUROPSYCHOBIOLOGY, 2020, 79 (01) : 108 - 116
  • [6] Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression
    Silvers, KM
    Woolley, CC
    Hamilton, FC
    Watts, PM
    Watson, RA
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2005, 72 (03): : 211 - 218
  • [7] The effectiveness of a Lactobacillus probiotic on measures of psychosocial health in adults diagnosed with subthreshold depression: a double-blind, randomised, placebo-controlled trial
    Moschonis, G.
    Sarapis, K.
    Resciniti, S.
    Hall, R.
    Yim, K.
    Tonkovic, M.
    Fitzgerald, C.
    Anixiadis, F.
    Dinh, Q. Nhu
    Hale, M.
    Wright, B.
    Pane, M.
    Tuck, C. J.
    Biesiekierski, J. R.
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2024, 83 (OCE1)
  • [8] Randomised, double-blind, placebo-controlled trial of EPs 7630 in adults with COPD
    Matthys, Heinrich
    Pliskevich, Dina A.
    Bondarchuk, Oleksandr M.
    Malek, Fathi A.
    Tribanek, Michael
    Kieser, Meinhard
    RESPIRATORY MEDICINE, 2013, 107 (05) : 691 - 701
  • [9] Montelukast for postinfectious cough in adults: a double-blind randomised placebo-controlled trial
    Wang, Kay
    Birring, Surinder S.
    Taylor, Kathryn
    Fry, Norman K.
    Hay, Alastair D.
    Moore, Michael
    Jin, Jing
    Perera, Rafael
    Farmer, Andrew
    Little, Paul
    Harrison, Timothy G.
    Mant, David
    Harnden, Anthony
    LANCET RESPIRATORY MEDICINE, 2014, 2 (01): : 35 - 43
  • [10] Metformin for knee osteoarthritis with obesity: study protocol for a randomised, double-blind, placebo-controlled trial
    Lim, Yuan Z.
    Wang, Yuanyuan
    Urquhart, Donna M.
    Estee, Mahnuma Mahfuz
    Wluka, Anita E.
    Heritier, Stephane
    Cicuttini, Flavia M.
    BMJ OPEN, 2023, 13 (12):