IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population

被引：9

作者：

Wang, Fei ^{[1
]}

Zhang, Yingai ^{[2
]}

Wang, Shunlan ^{[2
]}

Zhang, Yadong ^{[3
]}

Wu, Dinglan ^{[4
]}

Zhang, Chong ^{[5
]}

Gao, Yuanhui ^{[2
]}

Liu, Xi ^{[2
]}

Wang, Weifu ^{[1
]}

Zhang, Shufang ^{[2
]}

机构：

[1] Peoples Hosp Hainan Prov, Dept Urol, Haikou 570311, Hainan, Peoples R China

[2] Cent S Univ, Xiangya Sch Med, Affiliated Haikou Hosp, Cent Lab,Haikou Peoples Hosp, Haikou 570208, Hainan, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou 510080, Guangdong, Peoples R China

[4] Southern Med Univ, Shenzhen Hosp, Cent Lab, Shenzhen 518110, Guangdong, Peoples R China

[5] Cent S Univ, Dept Urol, Haikou Peoples Hosp, Xiangya Sch Med,Affiliated Haikou Hosp, Haikou 570208, Hainan, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 34期

基金：

中国国家自然科学基金;

关键词：

renal cell carcinoma (RCC); case-control studies; IL1; single-nucleotide polymorphism (SNP); GENOME-WIDE ASSOCIATION; GROWTH-FACTOR; CANCER; DISEASE; INTERLEUKIN-4; INFLAMMATION; CYTOKINES; RESPONSES; FAMILY; KIDNEY;

D O I：

10.18632/oncotarget.18715

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Renal cell carcinoma (RCC) is considered a cytokine-responsive tumor. However, with the lack of diagnostic screening biomarkers, early diagnosis of RCC is challenging. Our study was investigated the association of IL1 gene polymorphisms and RCC risk. We conducted a case-control study of 291 RCC cases and 463 controls to evaluation the IL1RN of single nucleotide polymorphisms (SNPs) on RCC risk. We selection of 16 SNPs in IL1RN, IL1A, IL1B genes were analyzed. Using the chi-squared (chi(2)) test and genetic model analysis, we found an association with RCC risk for five SNPs [rs3783550 (IL1A), rs3783546 (IL1A), rs1609682 (IL1A), rs3783521 (IL1A), and rs1143623 (IL1B)] and increased the risk of RCC. Stratified analyses show that smoking, not drinking and age>55 populations relative to nonsmoking, drinking and age<55 more susceptible. Our study suggested that IL1B and IL1A may involve in the development of RCC in Chinese Han population.

引用

页码：56021 / 56029

页数：9

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