N-methyl-D-aspartate prevented memory deficits induced by MK-801 in mice

被引：10
|
作者：
Hlinák, Z
Krejcí, I
机构：
[1] Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague 4, Czech Republic
[2] Charles Univ Prague, Fac Med 1, Dept Pharmacol, Prague, Czech Republic
来源：
PHYSIOLOGICAL RESEARCH | 2003年 / 52卷 / 06期
关键词：
N-methyl-D-aspartate; MK-801; spatial memory; elevated plus-maze; mice;
D O I：
10.33549/physiolres.930428
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
An interaction between N-methyl-D-aspartate (NMDA) and MK-801 was examined in mice using a modified elevated plus-maze paradigm that allows assessment of the adaptive form of spatial memory. NMDA administered (s.c.) immediately after the acquisition session protected the animals against the amnesia induced by MK-801 given shortly before the retention session. Behavioral performance, expressed as the transfer latency, and therefore spatial memory potency of NMDA plus MK-801 treated animals was comparable with that of both NMDA-treated animals and the controls.
引用
收藏
页码：809 / 812
页数：4
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