N-methyl-D-aspartate prevented memory deficits induced by MK-801 in mice

被引：10
|
作者：
Hlinák, Z
Krejcí, I
机构：
[1] Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague 4, Czech Republic
[2] Charles Univ Prague, Fac Med 1, Dept Pharmacol, Prague, Czech Republic
来源：
PHYSIOLOGICAL RESEARCH | 2003年 / 52卷 / 06期
关键词：
N-methyl-D-aspartate; MK-801; spatial memory; elevated plus-maze; mice;
D O I：
10.33549/physiolres.930428
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
An interaction between N-methyl-D-aspartate (NMDA) and MK-801 was examined in mice using a modified elevated plus-maze paradigm that allows assessment of the adaptive form of spatial memory. NMDA administered (s.c.) immediately after the acquisition session protected the animals against the amnesia induced by MK-801 given shortly before the retention session. Behavioral performance, expressed as the transfer latency, and therefore spatial memory potency of NMDA plus MK-801 treated animals was comparable with that of both NMDA-treated animals and the controls.
引用
收藏
页码：809 / 812
页数：4
相关论文
共 50 条
  • [1] THE ANTICONVULSANT MK-801 IS A POTENT N-METHYL-D-ASPARTATE ANTAGONIST
    WONG, EHF
    KEMP, JA
    PRIESTLEY, T
    KNIGHT, AR
    WOODRUFF, GN
    IVERSEN, LL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) : 7104 - 7108
  • [2] ANTICATALEPTIC EFFECTS OF THE N-METHYL-D-ASPARTATE ANTAGONIST MK-801 IN RATS
    SCHMIDT, WJ
    BUBSER, M
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (03) : 621 - 623
  • [3] INHIBITION OF N-METHYL-D-ASPARTATE EVOKED SODIUM FLUX BY MK-801
    RANSOM, RW
    STEC, NL
    [J]. BRAIN RESEARCH, 1988, 444 (01) : 25 - 32
  • [4] Effects of N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice
    Kiyohara, Shuichi
    Sakai, Nobuhiro
    Handa, Kazuaki
    Yamakawa, Tomoyuki
    Ishikawa, Koji
    Chatani, Masahiro
    Karakawa, Akiko
    Azetsu, Yuki
    Munakata, Motohiro
    Ozeki, Masahiko
    Negishi-Koga, Takako
    Takami, Masamichi
    [J]. JOURNAL OF ORAL BIOSCIENCES, 2020, 62 (02) : 131 - 138
  • [5] Differential effects of the N-methyl-D-aspartate receptor antagonist MK-801 on different stages of object recognition memory in mice
    Nilsson, M.
    Hansson, S.
    Carlsson, A.
    Carlsson, M. L.
    [J]. NEUROSCIENCE, 2007, 149 (01) : 123 - 130
  • [6] Suppression of autotomy by N-methyl-D-aspartate receptor antagonist (MK-801) in the rat
    Tseng, SH
    [J]. NEUROSCIENCE LETTERS, 1998, 240 (01) : 17 - 20
  • [7] THE INTERACTION BETWEEN MK-801 AND RECEPTORS FOR N-METHYL-D-ASPARTATE - FUNCTIONAL CONSEQUENCES
    WOODRUFF, GN
    FOSTER, AC
    GILL, R
    KEMP, JA
    WONG, EHF
    IVERSEN, LL
    [J]. NEUROPHARMACOLOGY, 1987, 26 (7B) : 903 - 909
  • [8] Effects of the N-methyl-D-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration
    Svalbe, Baiba
    Stelfa, Gundega
    Vavers, Edijs
    Zvejniece, Baiba
    Grinberga, Solveiga
    Sevostjanovs, Eduards
    Pugovics, Osvalds
    Dambrova, Maija
    Zvejniece, Liga
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2019, 372
  • [9] N-METHYL-D-ASPARTATE ANTAGONIST MK-801 FAILS TO BLOCK PHENCYCLIDINE-INDUCED BEHAVIORAL SENSITIZATION
    XU, X
    DOMINO, EF
    [J]. JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S285 - S285
  • [10] THE NATURE AND TIME-COURSE OF NEURONAL VACUOLATION INDUCED BY THE N-METHYL-D-ASPARTATE ANTAGONIST MK-801
    AUER, RN
    COULTER, KC
    [J]. ACTA NEUROPATHOLOGICA, 1994, 87 (01) : 1 - 7
12345