Inactivating Gene Expression with Antisense Modified Oligonucleotides

被引：0

作者：

Altman, Sidney ^{[1
,2
]}

Angele-Martinez, Carlos ^{[1
]}

机构：

[1] Yale Univ, New Haven, CT 06520 USA

[2] Arizona State Univ, Tempe, AZ 85281 USA

来源：

ACTA NATURAE | 2021年 / 13卷 / 03期

关键词：

modified nucleotides; gene expression; bacteria; Plasmodium falciparum; citrus plants; CELL-PENETRATING PEPTIDE; RIBONUCLEASE-P; ESCHERICHIA-COLI; THERAPEUTICS; CONJUGATE; SUBUNIT;

D O I：

10.32607/actanaturae.11522

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides.

引用

页码：101 / 105

页数：5

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