Inactivating Gene Expression with Antisense Modified Oligonucleotides

被引：0
|
作者：
Altman, Sidney [1 ,2 ]
Angele-Martinez, Carlos [1 ]
机构：
[1] Yale Univ, New Haven, CT 06520 USA
[2] Arizona State Univ, Tempe, AZ 85281 USA
来源：
ACTA NATURAE | 2021年 / 13卷 / 03期
关键词：
modified nucleotides; gene expression; bacteria; Plasmodium falciparum; citrus plants; CELL-PENETRATING PEPTIDE; RIBONUCLEASE-P; ESCHERICHIA-COLI; THERAPEUTICS; CONJUGATE; SUBUNIT;
D O I：
10.32607/actanaturae.11522
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides.
引用
收藏
页码：101 / 105
页数：5
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