Ixekizumab, a novel anti-IL-17A antibody, exhibits low immunogenicity during long-term treatment in patients with psoriasis

被引:0
|
作者
Blauvelt, Andrew [1 ]
Langley, Richard [2 ]
Leonardi, Craig [3 ]
Gordon, Kenneth [4 ]
Luger, Thomas [5 ]
Ohtsuki, Mamitoro [6 ]
Nickoloff, Brian [7 ]
Kerr, Lisa [7 ]
Cameron, Gregory [7 ]
Reich, Kristian [8 ]
机构
[1] Oregon Med Res Ctr, Portland, OR USA
[2] Dalhousie Univ, Halifax, NS, Canada
[3] Cent Dermatol, St Louis, MO USA
[4] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[5] Univ Munster, Munster, Germany
[6] Jichi Med Univ, Shimotsuke, Japan
[7] Eli Lilly & Co, Indianapolis, IN 46285 USA
[8] Dermatologikum Hamburg, Hamburg, Germany
关键词
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
3232
引用
收藏
页码:AB258 / AB258
页数:1
相关论文
共 50 条
  • [11] IMMUNOGENICITY OF THE NOVEL ANTI-IL-17A ANTIBODY, SECUKINUMAB, WITH INTRAVENOUS AND SUBCUTANEOUS DOSING REGIMENS IN HEALTHY SUBJECTS AND PATIENTS
    Klein, U.
    Liang, E.
    Vogel, B.
    Kolbinger, F.
    Bruin, G.
    Lloyd, P.
    ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 : 630 - 630
  • [12] Secukinumab: a review of the anti-IL-17A biologic for the treatment of psoriasis
    Frieder, Jillian
    Kivelevitch, Dario
    Menter, Alan
    THERAPEUTIC ADVANCES IN CHRONIC DISEASE, 2018, 9 (01) : 5 - 21
  • [13] Secukinumab, a novel anti-IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity
    Karle, Anette
    Spindeldreher, Sebastian
    Kolbinger, Frank
    MABS, 2016, 8 (03) : 536 - 550
  • [14] Response of a CARD14-associated papulosquamous eruption to the anti-IL-17A antibody ixekizumab
    Klein, Benjamin
    Treudler, Regina
    Dumann, Konstantin
    Boldt, Andreas
    Schumann, Isabell
    Simon, Jan Christoph
    Kunz, Manfred
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2023, 21 : 3 - 3
  • [15] Secukinumab, a novel anti IL-17A antibody, exhibits low immunogenicity in clinical trials and human in vitro assays
    Reich, Kristian
    Blauvelt, Andrew
    Armstrong, April
    Fox, Todd
    Huang, Jiaqing
    Liang, Eric
    Karle, Anette
    Spindeldreher, Sebastian
    Bruin, Gerard
    Kolbinger, Frank
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2015, 72 (05) : AB252 - AB252
  • [16] Population Pharmacokinetics of Xeligekimab: An Anti-IL-17A Monoclonal Antibody, in Patients with Moderate to Severe Plaque Psoriasis
    Meng, Qingheng
    Wang, Wei
    Zhang, Lingxiao
    Shi, Haiyang
    Liu, Hongxia
    Zheng, Qingshan
    Xu, Ling
    JOURNAL OF CLINICAL PHARMACOLOGY, 2025, 65 (01): : 53 - 65
  • [17] Results after at least 52 weeks of open label treatment with ixekizumab, an anti-IL-17A monoclonal antibody, in a phase 2 study in chronic plaque psoriasis
    Gordon, Kenneth
    Leonardi, Craig
    Braun, Daniel
    Cameron, Gregory
    Erickson, Janelle
    Lebwohl, Mark
    Heffernan, Michael
    Banerjee, Subhashis
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2014, 70 (05) : AB183 - AB183
  • [18] Challenges of systemic IL-17A quantification in patients treated with secukinumab, an anti-IL-17A antibody
    Calonder, C.
    Helbaj, R.
    Spindeldreher, S.
    Lloyd, P.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 : S22 - S22
  • [19] Preliminary Investigation and Therapeutic Efficacy Determination of a Novel Anti-IL-17A Antibody, Indikizumab
    Patra, Ashok Kumar
    Nayak, Shreenath
    Moharana, Anandita
    Ojha, Purusottam
    Das, Sanjeet Kumar
    Akhtar, Jabed
    Giri, Bishwaranjan
    Singh, Sujay
    BIOLOGICS-TARGETS & THERAPY, 2024, 18 : 257 - 271
  • [20] Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits low immunogenicity in psoriasis patients treated up to 5 years
    Reich, K.
    Blauvelt, A.
    Armstrong, A.
    Langley, R. G.
    de Vera, A.
    Kolbinger, F.
    Spindeldreher, S.
    Ren, M.
    Bruin, G.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2019, 33 (09) : 1733 - 1741