Inhibition of Dihydroorotate Dehydrogenase (DHODH) by RP7214 attenuates growth and promotes differentiation of AML cell lines

被引：0
|
作者：
Viswanadha, Srikant [1 ]
Eleswarapu, Satyanarayana [2 ]
Vakkalanka, Swaroop [1 ]
机构：
[1] Rhizen Pharmaceut SA, La Chaux De Fonds, Switzerland
[2] Incozen Therapeut Pvt Ltd, Hyderabad, India
来源：
MOLECULAR CANCER THERAPEUTICS | 2019年 / 18卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-19-C042
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
C042
引用
收藏
页数：2
相关论文
共 28 条
  • [1] RP7214, a small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), potentiates activity of Gilteritinib and Cytarabine in preclinical models of AML
    Viswanadha, Srikant
    Eleswarapu, Satyanarayana
    Penmetsa, Kumar V.
    Vakkalanka, Swaroop
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [2] A novel, small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), RP7214, potentiates activity of chemotherapeutics in breast and colorectal cancers
    Azmi, Asfar S.
    Aboukameel, Amro
    Al-Hallak, Mohammad Najeeb
    Philip, Philip A.
    Penmetsa, Kumar
    Visvanadha, Srikant
    Mpilla, Gabriel
    Sexton, Rachel
    Mohammad, Ramzi M.
    CANCER RESEARCH, 2020, 80 (16)
  • [3] Activity of RP7214, a novel, selective, and potent small molecule inhibitor of DHODH, in AML
    Viswanadha, Srikant
    Eleswarapu, Satyanarayana
    Vakkalanka, Swaroop
    CANCER RESEARCH, 2022, 82 (12)
  • [4] A first in man study to evaluate the safety, pharmacokinetics and pharmacodynamics of RP7214, a dihydroorotate dehydrogenase inhibitor in healthy subjects
    Nair, Ajit
    Barde, Prajak J.
    Routhu, Kasi, V
    Viswanadha, Srikant
    Veeraraghavan, Sridhar
    Pak, Samuel
    Peterson, Jeffrey A.
    Vakkalanka, Swaroop
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2023, 89 (03) : 1127 - 1138
  • [5] Inhibition of growth and induction of differentiation of glioma cell lines by oncostatin M (OSM)
    Halfter, H
    Lotfi, R
    Westermann, R
    Young, P
    Ringelstein, EB
    Stögbauer, FT
    GROWTH FACTORS, 1998, 15 (02) : 135 - 147
  • [6] Growth inhibition and differentiation of pancreatic cancer cell lines by PPARγ ligand troglitazone
    Kawa, S
    Nikaido, T
    Unno, H
    Usuda, N
    Nakayama, K
    Kiyosawa, K
    PANCREAS, 2002, 24 (01) : 1 - 7
  • [7] Inhibition of Class-3 aldehyde dehydrogenase and cell growth by restored lipid peroxidation in hepatoma cell lines
    Canuto, RA
    Muzio, G
    Ferro, M
    Maggiora, M
    Federa, R
    Bassi, AM
    Lindahl, R
    Dianzani, MU
    FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (3-4) : 333 - 340
  • [8] GROWTH-INHIBITION AND PROMOTION OF DIFFERENTIATION INDUCTION IN CULTURED LEUKEMIA-CELL LINES BY DEFEROXAMINE
    TOMOYASU, S
    NAKAMAKI, T
    SUZUKI, K
    TSURUOKA, N
    ACTA HAEMATOLOGICA JAPONICA, 1987, 50 (03): : 568 - 574
  • [9] Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines
    Kim, Hea-In
    Moon, Sun-Ha
    Lee, Won-Cheol
    Lee, Hyeon-Jeong
    Shivakumar, Sharath Belame
    Lee, Sung-Ho
    Park, Bong-Wook
    Rho, Gyu-Jin
    Jeon, Byeong-Gyun
    ANIMAL CELLS AND SYSTEMS, 2018, 22 (03) : 178 - 188
  • [10] Targeting Lon Protease Activity Promotes Growth Inhibition and Apoptosis in Acute Myeloid Leukemia Cell Lines
    De Matteis, Serena
    Carloni, Silvia
    Napolitano, Roberta
    Zanoni, Michele
    Gibellini, Lara
    Lucchesi, Alessandro
    Cossarizza, Andrea
    Martinelli, Giovanni
    BLOOD, 2014, 124 (21)
123