RP7214, a small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), potentiates activity of Gilteritinib and Cytarabine in preclinical models of AML

被引：0
|
作者：
Viswanadha, Srikant [1 ]
Eleswarapu, Satyanarayana [2 ]
Penmetsa, Kumar V. [1 ]
Vakkalanka, Swaroop [1 ]
机构：
[1] Rhizen Pharmaceut SA, La Chaux De Fonds, Switzerland
[2] Incozen Therapeut Pvt Ltd, Hyderabad, India
来源：
MOLECULAR CANCER THERAPEUTICS | 2019年 / 18卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-19-C044
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
C044
引用
收藏
页数：2
相关论文
共 24 条
  • [1] A novel, small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), RP7214, potentiates activity of chemotherapeutics in breast and colorectal cancers
    Azmi, Asfar S.
    Aboukameel, Amro
    Al-Hallak, Mohammad Najeeb
    Philip, Philip A.
    Penmetsa, Kumar
    Visvanadha, Srikant
    Mpilla, Gabriel
    Sexton, Rachel
    Mohammad, Ramzi M.
    CANCER RESEARCH, 2020, 80 (16)
  • [2] Activity of RP7214, a novel, selective, and potent small molecule inhibitor of DHODH, in AML
    Viswanadha, Srikant
    Eleswarapu, Satyanarayana
    Vakkalanka, Swaroop
    CANCER RESEARCH, 2022, 82 (12)
  • [3] Inhibition of Dihydroorotate Dehydrogenase (DHODH) by RP7214 attenuates growth and promotes differentiation of AML cell lines
    Viswanadha, Srikant
    Eleswarapu, Satyanarayana
    Vakkalanka, Swaroop
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [4] RP4010, a small molecule inhibitor of Store-Operated Calcium Entry (SOCE), potentiates activity of Gilteritinib and Cytarabine in preclinical models of AML
    Viswanadha, Srikant
    Eleswarapu, Satyanarayana
    Penmetsa, Kumar V.
    Vakkalanka, Swaroop
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [5] A first in man study to evaluate the safety, pharmacokinetics and pharmacodynamics of RP7214, a dihydroorotate dehydrogenase inhibitor in healthy subjects
    Nair, Ajit
    Barde, Prajak J.
    Routhu, Kasi, V
    Viswanadha, Srikant
    Veeraraghavan, Sridhar
    Pak, Samuel
    Peterson, Jeffrey A.
    Vakkalanka, Swaroop
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2023, 89 (03) : 1127 - 1138
  • [6] A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models
    Lightcap, Eric S.
    Yu, Pengfei
    Grossman, Stephen
    Song, Keli
    Khattar, Mithun
    Xega, Kristina
    He, Xingyue
    Gavin, James M.
    Imaichi, Hisashi
    Garnsey, James J.
    Koenig, Erik
    Zhang, Hongru
    Lu, Zhen
    Shah, Pooja
    Fu, Yu
    Milhollen, Michael A.
    Hatton, Beryl A.
    Riceberg, Jessica
    Shinde, Vaishali
    Li, Cong
    Minissale, James
    Yang, Xiaofeng
    England, Dylan
    Klinghoffer, Richard A.
    Langston, Steve
    Galvin, Katherine
    Shapiro, Gary
    Pulukuri, Sai M.
    Fuchs, Serge Y.
    Huszar, Dennis
    SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (611)
  • [7] Discovery and structure-activity relationship (SAR) of BRD7539, a small molecule inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH)
    Maetani, Micah
    Kato, Nobutaka
    Ross, Leila
    Comer, Eamon
    Scherer, Christina
    Wirth, Dyann
    Schreiber, Stuart
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [8] RP12146, a novel, selective, and potent small molecule inhibitor of PARP 1/2, synergizes with SOC therapy in preclinical models of solid tumors
    Viswanadha, S.
    Eleswarapu, S.
    Karnam, K.
    Vakkalanka, S.
    EUROPEAN JOURNAL OF CANCER, 2022, 174 : S33 - S33
  • [9] NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models
    Michael Rugaard Jensen
    Joseph Schoepfer
    Thomas Radimerski
    Andrew Massey
    Chantale T Guy
    Josef Brueggen
    Cornelia Quadt
    Alan Buckler
    Robert Cozens
    Martin J Drysdale
    Carlos Garcia-Echeverria
    Patrick Chène
    Breast Cancer Research, 10
  • [10] NVP-AUY922:: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models
    Jensen, Michael Rugaard
    Schoepfer, Joseph
    Radimerski, Thomas
    Massey, Andrew
    Guy, Chantale T.
    Brueggen, Josef
    Quadt, Cornelia
    Buckler, Alan
    Cozens, Robert
    Drysdale, Martin J.
    Garcia-Echeverria, Carlos
    Chene, Patrick
    BREAST CANCER RESEARCH, 2008, 10 (02)
123