Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

被引：25
|
作者：
Vilas-Boas, Vania [1 ]
Gijbels, Eva [1 ]
Jonckheer, Joop [2 ]
De Waele, Elisabeth [2 ]
Vinken, Mathieu [1 ]
机构：
[1] Vrije Univ Brussel, Dept In Vitro Toxicol & Dermatocosmetol, Laarbeeklaan 103, B-1090 Brussels, Belgium
[2] UZ Brussel, Dept Intens Care, Laarbeeklaan 101, B-1090 Brussels, Belgium
来源：
ENVIRONMENT INTERNATIONAL | 2020年 / 136卷
关键词：
Cholestasis; Food additives; Dietary supplements; Herbal supplements; Parenteral nutrition; PRIMARY BILIARY-CIRRHOSIS; WATER CLAM EXTRACT; BILE-ACID; HEPATIC-FUNCTION; HEPATOTOXICITY; INFANTS; TARTRAZINE; TOXICITY; CHILDREN; DISEASE;
D O I：
10.1016/j.envint.2019.105422
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective bile secretion. This pathological situation can be triggered by drugs, but also by ingredients contained in food, food supplements and parenteral nutrition. This paper provides an overview of the current knowledge on cholestatic injury associated with such ingredients, with particular emphasis on the underlying mechanisms of toxicity.
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页数：11
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