The effects of gut microbiota on metabolic outcomes in pregnant women and their offspring

被引:8
|
作者
Lv, You [1 ]
Yan, Zi [1 ]
Zhao, Xue [1 ]
Gang, Xiaokun [1 ]
He, Guangyu [1 ]
Sun, Lin [1 ]
Li, Zhuo [1 ]
Wang, Guixia [1 ]
机构
[1] Jilin Univ, Hosp 1, Dept Endocrinol & Metab, Changchun, Jilin, Peoples R China
基金
美国国家科学基金会;
关键词
CHAIN FATTY-ACIDS; GESTATIONAL DIABETES-MELLITUS; SYNBIOTIC FOOD-CONSUMPTION; PROBIOTIC SUPPLEMENTATION; INTESTINAL MICROBIOTA; ANTIBIOTIC-TREATMENT; INSULIN SENSITIVITY; GLUCOSE-METABOLISM; FECAL MICROBIOTA; DIETARY-INTAKE;
D O I
10.1039/c8fo00601f
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metabolic diseases such as gestational diabetes mellitus and obesity during pregnancy have become severe health issues due to adverse pregnant outcomes in recent years. Maternal metabolic disorders can influence the long-term health of mothers and their offspring. Current evidence demonstrated that gut microbiota plays a crucial role in metabolic dysfunction during gestation. Maternal status is associated with alterations in the compositions and diversity of the intestinal microbiota community during gestation. Antibiotic treatments may disturb the gut microbiota of pregnant women, and scientific probiotic and prebiotic supplements have positive effects on mothers and their offspring. This review discusses the role of gut microbiota on metabolic outcomes in pregnant women and their offspring, and further illustrates the impact of interventions on metabolic disorders in pregnancy. Our study may provide a novel target for health management during pregnancy.
引用
收藏
页码:4537 / 4547
页数:11
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