RETRACTED: Correlation between changes in gut flora and serum inflammatory factors in children with noninfectious diarrhea (Retracted Article)

Purpose: To assess the association between changes in gut flora and serum inflammatory factors in children with noninfectious diarrhea. Basic Procedure: Ninety-three children diagnosed with and treated for noninfectious diarrhea (diarrhea group) and 80 healthy children (healthy control group) were enrolled in this study. Fresh fecal samples were diluted, and after cultivating bacteria for 48 hours at 37 degrees C, we compared the number of bacterial cells in gut flora per gram of feces and determined gut colonization resistance. Findings: The abundance of Escherichia coli and Enterococcus in feces was significantly higher in the diarrhea group than in the healthy control group. Conversely, the abundance of Bifidobacterium and lactic acid bacteria was significantly lower in the diarrhea group than in the healthy control group. Serum interleukin (IL)-1, IL-6, IL-17, and tumor necrosis factor (TNF)-alpha levels in the diarrhea group were significantly higher than those in the healthy control group. Pearson's correlation analysis revealed that serum IL-1, IL-6, IL-17, and TNF-alpha levels positively correlated with abundance of E. coli and Enterococcus and negatively correlated with abundance of Bifidobacterium and lactic acid bacteria. Conclusions: Gut dysbacteriosis and overexpression of serum inflammatory factors occur in children with noninfectious diarrhea and are closely correlated.