Are DNA-HLA class II interactions the missing link in SLE?

被引：0
|
作者：
Pisetsky, David S. [1 ,2 ]
机构：
[1] Duke Univ, Med Ctr, Dept Med & Immunol, Durham, NC 27708 USA
[2] Durham VA Med Ctr, Med Res Serv, Durham, NC 27705 USA
来源：
NATURE REVIEWS RHEUMATOLOGY | 2021年 / 17卷 / 11期
关键词：
COMPLEXES; AUTOANTIBODIES;
D O I：
10.1038/s41584-021-00684-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
New evidence has emerged that DNA can bind to cell surface HLA class II molecules. If true, this surprising interaction could lead to T cell and B cell activation by DNA, and surface DNA could also provide a target for cell killing by anti-DNA antibodies in systemic lupus erythematosus.
引用
收藏
页码：647 / 648
页数：2
相关论文
共 50 条
  • [41] HLA Class II Specificity Assessed by High-Density Peptide Microarray Interactions
    Osterbye, Thomas
    Nielsen, Morten
    Dudek, Nadine L.
    Ramarathinam, H.
    Purcell, Anthony W.
    Schafer-Nielsen, Claus
    Buus, Soren
    [J]. JOURNAL OF IMMUNOLOGY, 2020, 205 (01): : 290 - 299
  • [42] ALLELIC COMPETITION IN PEPTIDE/HLA CLASS-II ALPHA-BETA INTERACTIONS
    KOVATS, S
    BLUM, JS
    SETTE, A
    SAKAGUCHI, K
    APPELLA, E
    KWOK, W
    NEPOM, GT
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 69 - 69
  • [43] Unbiased Characterization of Peptide-HLA Class II Interactions Based on Large-Scale Peptide Microarrays; Assessment of the Impact on HLA Class II Ligand and Epitope Prediction
    Wendorff, Mareike
    Garcia Alvarez, Heli M.
    Osterbye, Thomas
    ElAbd, Hesham
    Rosati, Elisa
    Degenhardt, Frauke
    Buus, Sren
    Franke, Andre
    Nielsen, Morten
    [J]. FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [44] HLA class I and class II antigens in sarcoidosis
    Morar, R.
    Duarte, R.
    Wadee, A. A.
    Feldman, C.
    [J]. SAMJ SOUTH AFRICAN MEDICAL JOURNAL, 2022, 112 (12): : 904 - 910
  • [45] The arrival of HLA class II tetramers
    McMichael, AJ
    Kelleher, A
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (12): : 1669 - 1670
  • [46] Folate and colorectal carcinogenesis: Is DNA repair the missing link?
    Choi, SW
    Mason, JB
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 1998, 93 (11): : 2013 - 2016
  • [47] HLA - Class II association and myasthenia
    Gekht, BM
    Agafonov, BV
    Tzuman, VG
    Lebedeva, LL
    Sidorova, OP
    Nalivkin, AE
    [J]. HUMAN IMMUNOLOGY, 1996, 47 (1-2) : P164 - P164
  • [48] HLA class II DNA genotyping by TMA-HPA method for kidney transplantation
    Junji, S
    Ranko, H
    Akira, K
    Hiroo, M
    [J]. HUMAN IMMUNOLOGY, 1996, 47 (1-2) : P237 - P237
  • [49] HLA CLASS II TYPING BASED ON THE SIZE POLYMORPHISM OF DNA RESTRICTION FRAGMENTS (RFLP)
    ALDACCAK, R
    LOISEAU, P
    COLOMBANI, J
    [J]. REVUE FRANCAISE DE TRANSFUSION ET D HEMOBIOLOGIE, 1990, 33 (03): : 175 - 201
  • [50] DNA typing of HLA class II genes in Japanese patients with rheumatic heart disease
    Koyanagi, T
    Koga, Y
    Nishi, H
    Toshima, H
    Sasazuki, T
    Imaizumi, T
    Kimura, A
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1996, 28 (06) : 1349 - 1353
12345