Are DNA-HLA class II interactions the missing link in SLE?

被引：0
|
作者：
Pisetsky, David S. [1 ,2 ]
机构：
[1] Duke Univ, Med Ctr, Dept Med & Immunol, Durham, NC 27708 USA
[2] Durham VA Med Ctr, Med Res Serv, Durham, NC 27705 USA
来源：
NATURE REVIEWS RHEUMATOLOGY | 2021年 / 17卷 / 11期
关键词：
COMPLEXES; AUTOANTIBODIES;
D O I：
10.1038/s41584-021-00684-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
New evidence has emerged that DNA can bind to cell surface HLA class II molecules. If true, this surprising interaction could lead to T cell and B cell activation by DNA, and surface DNA could also provide a target for cell killing by anti-DNA antibodies in systemic lupus erythematosus.
引用
收藏
页码：647 / 648
页数：2
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