Expression of Human Thrombomodulin on GTKO. CD46 Donor Pigs and Costimulation Blockade by Anti CD40 Antibody is Critical for Extending Cardiac Xenograft Survival in Non-human Primates

被引：0
|
作者：
Singh, Avneesh [1 ,4 ]
DiChiacchio, Laura [4 ]
Chan, Joshua L. [1 ]
Lewis, Billeta G. T. [2 ]
Thomas, Marvin L. [2 ]
Corcoran, Philip C. [1 ]
Ayares, David [3 ]
Horvath, Keith A. [1 ]
Mohiuddin, Muhammad M. [1 ,4 ]
机构：
[1] NHLBI, Cardiothorac Surg Res Program, NIH, Bldg 10, Bethesda, MD 20892 USA
[2] NIH, Div Vet Resources, Off Res Serv, Bldg 10, Bethesda, MD 20892 USA
[3] Revivicor Inc, Blacksburg, VA USA
[4] Univ Maryland, Dept Surg, Baltimore, MD 21201 USA
来源：
TRANSPLANTATION | 2018年 / 102卷
关键词：
D O I：
10.1097/01.tp.0000543732.72476.8d
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P.535
引用
收藏
页码：S741 / S741
页数：1
相关论文
共 33 条
  • [21] Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
    Muhammad M. Mohiuddin
    Avneesh K. Singh
    Philip C. Corcoran
    Marvin L. Thomas III
    Tannia Clark
    Billeta G. Lewis
    Robert F. Hoyt
    Michael Eckhaus
    Richard N. Pierson III
    Aaron J. Belli
    Eckhard Wolf
    Nikolai Klymiuk
    Carol Phelps
    Keith A. Reimann
    David Ayares
    Keith A. Horvath
    Nature Communications, 7
  • [22] Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
    Mohiuddin, Muhammad M.
    Singh, Avneesh K.
    Corcoran, Philip C.
    Thomas, Marvin L., III
    Clark, Tannia
    Lewis, Billeta G.
    Hoyt, Robert F.
    Eckhaus, Michael
    Pierson, Richard N., III
    Belli, Aaron J.
    Wolf, Eckhard
    Klymiuk, Nikolai
    Phelps, Carol
    Reimann, Keith A.
    Ayares, David
    Horvath, Keith A.
    NATURE COMMUNICATIONS, 2016, 7
  • [23] Treatment of anti-CD20 antibody and tacrolimus promotes long-term survival of full thickness corneal xenotransplantation in non-human primates
    Choi, Se Hyun
    Kim, Jaeyoung
    Lee, Hyun Ju
    Kim, Hong Pyo
    Kang, Hee Jung
    Kim, Jong Min
    Park, Chung-Gyu
    Wee, Won Ryang
    Kim, Mee Kum
    XENOTRANSPLANTATION, 2017, 24 (05)
  • [24] Preclinical pharmacokinetics, pharmacodynamics and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates (vol 148, pg 1116, 2006)
    Kelley, S. K.
    Gelzleichter, T.
    Xie, D.
    Lee, W. P.
    Darbonne, W. C.
    Qureshi, F.
    Kissler, K.
    Oflazoglu, E.
    Grewal, I. S.
    BRITISH JOURNAL OF PHARMACOLOGY, 2007, 150 (02) : 248 - 248
  • [25] Long-Term Graft Acceptance by a Novel Human Anti-CD40 Monoclonal Antibody, 4D11, after Liver Transplantation in Non-Human Primates.
    Oura, Tetsu
    Yamashita, Kenichiro
    Suzuki, Tomomi
    Miura, Toru
    Haga, Hironori
    Shimizu, Akira
    Taniguchi, Masahiko
    Shimamura, Tsuyoshi
    Furukawa, Hiroyuki
    Todo, Satoru
    AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 : 319 - 319
  • [26] Long Term GalKO.hCD46. hTBM Pig Cardiac Xenograft Survival in Baboon May Be Dependent On Dose and Duration of Anti CD40 (2C10R4) Antibody.
    Mohiuddin, M.
    Singh, A.
    Corcoran, P.
    Hoyt, R.
    Thomas, M.
    Eckhaus, M.
    Lewis, B.
    Clark, T.
    Phelps, C.
    Ayares, D.
    Reimann, K.
    Horvath, K.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 : 415 - 415
  • [27] Long Term GalKO•hCD46. hTBM Pig Cardiac Xenograft Survival in Baboon May Be Dependent On Dose and Duration of Anti CD40 (2C10R4) Antibody.
    Mohiuddin, M.
    Singh, A.
    Corcoran, P.
    Hoyt, R.
    Thomas, M.
    Eckhaus, M.
    Lewis, B.
    Clark, T.
    Phelps, C.
    Ayares, D.
    Reimann, K.
    Horvath, K.
    TRANSPLANTATION, 2014, 98 : 415 - 415
  • [28] Low and tapering dose of anti CD40 (2C10 or 3A8) for 8-week duration fails to extend GTKO.hCD46Tg pig to baboon cardiac xenograft survival beyond 5 months
    Singh, Avneesh
    Corcoran, Philip
    Thomas, Marvin
    Hoyt, Robert
    Lewis, Billeta
    Clark, Tannia
    Eckhaus, Michael
    Reimann, Keith
    Ayares, David
    Horvath, Keith
    Mohiuddin, Muhammad
    XENOTRANSPLANTATION, 2013, 20 (05) : 342 - 342
  • [29] A NOVEL, BLOCKING ANTI-CD40 MONOCLONAL ANTIBODY PROLONGS NON-HUMAN PRIMATE RENAL ALLOGRAFT SURVIVAL IN THE ABSENCE OF B-CELL DEPLETION OR THROMBOEMBOLIC EVENTS
    Cordoba, Francisco
    Wieczorek, Grazyna
    Audet, Maxime
    Schneider, Martin A.
    Espie, Pascal
    Roth, Lukas
    Heusser, Christoph
    Bruns, Christian
    Patel, Dhavalkumar
    Haraldsson, Boerje
    Rush, James S.
    TRANSPLANT INTERNATIONAL, 2015, 28 : 123 - 123
  • [30] A novel, blocking anti-CD40 monoclonal antibody prolongs non-human primate renal allograft survival in the absence of B-cell depletion or thromboembolic events
    Cordoba, F.
    Wieczorek, G.
    Audet, M.
    Schneider, M.
    Espie, P.
    Roth, L.
    Heusser, C.
    Bruns, C.
    Patel, D.
    Rush, J.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 764 - 764
1234