Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures

被引:202
|
作者
Mostowy, Serge [1 ,5 ,6 ]
Bonazzi, Matteo [1 ,5 ,6 ]
Hamon, Melanie Anne [1 ,5 ,6 ]
Tham, To Nam [1 ,5 ,6 ]
Mallet, Adeline
Lelek, Mickael [2 ,7 ]
Gouin, Edith [1 ,5 ,6 ]
Demangel, Caroline [3 ]
Brosch, Roland [3 ]
Zimmer, Christophe [2 ,7 ]
Sartori, Anna
Kinoshita, Makoto [8 ]
Lecuit, Marc [4 ,9 ,10 ]
Cossart, Pascale [1 ,5 ,6 ]
机构
[1] Inst Pasteur, Unite Interact Bacteries Cellules, F-75015 Paris, France
[2] Inst Pasteur, Grp Imagerie & Modelisat, F-75015 Paris, France
[3] Inst Pasteur, Unite Postulante Pathogenom Mycobacterienne Integ, F-75015 Paris, France
[4] Inst Pasteur, Grp Microorganismes & Barrieres Hote, F-75015 Paris, France
[5] INSERM, U604, F-75015 Paris, France
[6] Inst Natl Rech Agronom, Unite Sous Contrat 2020, F-75015 Paris, France
[7] CNRS, Unite Rech Associee 2582, F-75015 Paris, France
[8] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Dept Mol Biol, Nagoya, Aichi 4648602, Japan
[9] INSERM, U604, F-75015 Paris, France
[10] Univ Paris 05, Ctr Infect Necker Pasteur, Serv Malad Infect & Trop, Hop Necker Enfants Malad,AP HP Paris, F-75015 Paris, France
基金
加拿大健康研究院; 欧洲研究理事会;
关键词
ACTIN-BASED MOTILITY; LISTERIA-MONOCYTOGENES; MAMMALIAN SEPTINS; MYOSIN-II; AUTOPHAGY; PROTEIN; CYTOKINESIS; SHIGELLA; INVASION; RECEPTOR;
D O I
10.1016/j.chom.2010.10.009
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Actin-based motility is used by various pathogens for dissemination within and between cells. Yet host factors restricting this process have not been identified. Septins are GTP-binding proteins that assemble as filaments and are essential for cell division. However, their role during interphase has remained elusive. Here, we report that septin assemblies are recruited to different bacteria that polymerize actin. We observed that intracytosolic Shigella either become compartmentalized in septin cage-like structures or form actin tails. Inactivation of septin caging increases the number of Shigella with actin tails and enhances cell-to-cell spread. TNF-alpha, a host cytokine produced upon Shigella infection, stimulates septin caging and restricts actin tail formation and cell-to-cell spread. Finally, we show that septin cages entrap bacteria targeted to autophagy. Together, these results reveal an unsuspected mechanism of host defense that restricts dissemination of invasive pathogens.
引用
收藏
页码:433 / 444
页数:12
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