Diffusion Tensor Magnetic Resonance Imaging for Differentiating Multiple System Atrophy Cerebellar Type and Spinocerebellar Ataxia Type 3

被引:10
|
作者
Jao, Chi-Wen [1 ,2 ,3 ]
Soong, Bing-Wen [4 ,5 ]
Huang, Chao-Wen [1 ]
Duan, Chien-An [1 ]
Wu, Chih-Chun [6 ,7 ]
Wu, Yu-Te [1 ,2 ]
Wang, Po-Shan [1 ,2 ,8 ]
机构
[1] Natl Yang Ming Univ, Inst Biophoton, Taipei 11221, Taiwan
[2] Natl Yang Ming Univ, Brain Res Ctr, Taipei 11221, Taiwan
[3] Shin Kong Wu Ho Su Mem Hosp, Dept Neurol, Taipei 11101, Taiwan
[4] Taipei Med Univ, Taipei Neurosci Inst, Taipei 11041, Taiwan
[5] Taipei Vet Gen Hosp, Dept Neurol, Taipei 11221, Taiwan
[6] Natl Yang Ming Univ, Sch Med, Taipei 11221, Taiwan
[7] Taipei Vet Gen Hosp, Dept Radiol, Taipei 11221, Taiwan
[8] Taipei Municipal Gan Dau Hosp, Neurol Inst, Taipei 11261, Taiwan
关键词
DTI; SCA3; MAS-C; cerebellum; K-means clustering; MACHADO-JOSEPH-DISEASE; WHITE-MATTER DAMAGE; SPATIAL STATISTICS; VOXEL; DEFICITS; VOLUME; PERMUTATION; INCLUSIONS; MR;
D O I
10.3390/brainsci9120354
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Multiple system atrophy cerebellar type (MSA-C) and spinocerebellar ataxia type 3 (SCA3) demonstrate similar manifestations, including ataxia, pyramidal and extrapyramidal signs, as well as atrophy and signal intensity changes in the cerebellum and brainstem. MSA-C and SCA3 cannot be clinically differentiated through T1-weighted magnetic resonance imaging (MRI) alone; therefore, clinical consensus criteria and genetic testing are also required. Here, we used diffusion tensor imaging (DTI) to measure water molecular diffusion of white matter and investigate the difference between MSA-C and SCA3. Four measurements were calculated from DTI images, including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD). Fifteen patients with MSA-C, 15 patients with SCA3, and 30 healthy individuals participated in this study. Both patient groups demonstrated a significantly decreased FA but a significantly increased AD, RD, and MD in the cerebello-ponto-cerebral tracts. Moreover, patients with SCA3 demonstrated a significant decrease in FA but more significant increases in AD, RD, and MD in the cerebello-cerebral tracts than patients with MSAC. Our results may suggest that FA and MD can be effectively used for differentiating SCA3 and MSA-C, both of which are cerebellar ataxias and have many common atrophied regions in the cerebral and cerebellar cortex.
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页数:14
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