Epitranscriptomics: regulation of mRNA metabolism through modifications

被引:90
|
作者
Peer, Eyal [1 ,2 ,3 ]
Rechavi, Gideon [1 ,2 ,3 ]
Dominissini, Dan [1 ,2 ,3 ]
机构
[1] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
[2] Chaim Sheba Med Ctr, Canc Res Ctr, Tel Hashomer, Israel
[3] Chaim Sheba Med Ctr, Wohl Ctr Translat Med, Tel Hashomer, Israel
关键词
TRANSLATION EFFICIENCY; METHYLATION; N-1-METHYLADENOSINE; N-6-METHYLADENOSINE; N6-METHYLADENOSINE; REVEALS; NUCLEAR; METHYLTRANSFERASE; THERMODYNAMICS; TRANSCRIPTION;
D O I
10.1016/j.cbpa.2017.10.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cellular RNAs can be modified post-transcriptionally with dynamic and reversible chemical modifications. These modifications can alter the structure and metabolism of mRNA, but only recent methodological and conceptual advances allowed systematic mapping and functional analysis to unfold the role they play in mRNA biology. Mapping the most common internal mRNA modification, N-6-methyladenosine (m(6)A), paved the way for the deciphering of other types of mRNA modifications, such as N-1-methyladenosine (m(1)A). RNA methylation provides dynamic regulation to the processing, export, translation and stability of mRNA molecules, thereby influencing fundamental biological and pathological processes such as differentiation, cellular response to stress and tumorigenesis. This review summarizes the key methods and the recent discoveries in the field of epitranscriptomics through the prism of post-transcriptional mRNA methylation in eukaryotes.
引用
收藏
页码:93 / 98
页数:6
相关论文
共 50 条
  • [31] Matrix Redox Physiology Governs the Regulation of Plant Mitochondrial Metabolism through Posttranslational Protein Modifications
    Moller, Ian Max
    Igamberdiev, Abir U.
    Bykova, Natalia V.
    Finkemeier, Iris
    Rasmusson, Allan G.
    Schwarzlaender, Markus
    PLANT CELL, 2020, 32 (03): : 573 - 594
  • [32] Epitranscriptomics: A New Layer of microRNA Regulation in Cancer
    De Paolis, Veronica
    Lorefice, Elisa
    Orecchini, Elisa
    Carissimi, Claudia
    Laudadio, Ilaria
    Fulci, Valerio
    CANCERS, 2021, 13 (13)
  • [33] Regulation and functions of non-m6A mRNA modifications
    Hanxiao Sun
    Kai Li
    Cong Liu
    Chengqi Yi
    Nature Reviews Molecular Cell Biology, 2023, 24 : 714 - 731
  • [34] Regulation and functions of non-m6A mRNA modifications
    Sun, Hanxiao
    Li, Kai
    Liu, Cong
    Yi, Chengqi
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2023, 24 (10) : 714 - 731
  • [35] Microglia Regulation of Neuronal Metabolism and mRNA Translation
    Adler, D.
    Avila, A. M.
    Gan, W. -B.
    Klann, E.
    GLIA, 2023, 71 : E380 - E381
  • [36] Epitranscriptomics and Flowering: mRNA Methylation/Demethylation Regulates Flowering Time
    Hofmann, Nancy R.
    PLANT CELL, 2017, 29 (12): : 2949 - 2950
  • [37] Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson's Disease
    Gionco, John T.
    Bernstein, Alison I.
    JOURNAL OF PARKINSONS DISEASE, 2024, 14 (04) : 643 - 656
  • [38] The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?
    Schaefer, Matthias R.
    GENES, 2021, 12 (03) : 1 - 19
  • [39] Publisher Correction: Post-transcriptional gene regulation by mRNA modifications
    Boxuan Simen Zhao
    Ian A. Roundtree
    Chuan He
    Nature Reviews Molecular Cell Biology, 2018, 19 : 808 - 808
  • [40] EPITRANSCRIPTOMICS Layered-up regulation in the developing brain
    Sweatt, J. David
    NATURE, 2017, 551 (7681) : 448 - 449