Combined Technologies for Microfabricating Elastomeric Cardiac Tissue Engineering Scaffolds

被引：52
|
作者：
Guillemette, Maxime D. [1 ]
Park, Hyoungshin [1 ]
Hsiao, James C. [2 ]
Jain, Saloni R. [1 ]
Larson, Benjamin L. [1 ]
Langer, Robert [1 ]
Freed, Lisa E. [1 ,2 ]
机构：
[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[2] Charles Stark Draper Lab Inc, Biomed Engn & MEMS Fabricat Grp, Cambridge, MA 02139 USA
来源：
MACROMOLECULAR BIOSCIENCE | 2010年 / 10卷 / 11期
关键词：
biodegradable; cell orientation; elastomers; microfabrication; tissue engineering; MECHANICAL-PROPERTIES; CELLS; HEART; TOPOGRAPHY; SURFACES; GRAFTS; MICRO; FIBROBLASTS; ORIENTATION; FABRICATION;
D O I：
10.1002/mabi.201000165
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polymer scaffolds that direct elongation and orientation of cultured cells can enable tissue engineered muscle to act as a mechanically functional unit. We combined micromolding and microablation technologies to create muscle tissue engineering scaffolds from the biodegradable elastomer poly(glycerol sebacate). These scaffolds exhibited well defined surface patterns and pores and robust elastomeric tensile mechanical properties. Cultured C2C12 muscle cells penetrated the pores to form spatially controlled engineered tissues. Scanning electron and confocal microscopy revealed muscle cell orientation in a preferential direction, parallel to micromolded gratings and long axes of microablated anisotropic pores, with significant individual and interactive effects of gratings and pore design.
引用
收藏
页码：1330 / 1337
页数：8
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