Mobile elements and mammalian genome evolution

被引：358
|
作者：
Deininger, PL
Moran, JV
Batzer, MA
Kazazian, HH
机构：
[1] Tulane Univ, Hlth Sci Ctr, Tulane Canc Ctr, New Orleans, LA 70112 USA
[2] Tulane Univ, Hlth Sci Ctr, Dept Environm Hlth Sci, New Orleans, LA 70112 USA
[3] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA
[5] Louisiana State Univ, Dept Biol Sci, Biol Computat & Visualizat Ctr, Baton Rouge, LA 70803 USA
[6] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 06期
关键词：
D O I：
10.1016/j.gde.2003.10.013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.
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页码：651 / 658
页数：8
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