SOLVENT-FREE ONE-POT SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF NOVEL SPIROPIPERIDINYL-1,2,4-TRIAZOLIDINE-3-THIONES

被引：7
|
作者：
Kanagarajan, V. [1 ]
Thanusu, J. [1 ]
Ezhilarasi, M. R. [1 ]
Gopalakrishnan, M. [1 ]
机构：
[1] Annamalai Univ, Dept Chem, Synthet Organ Chem Lab, Annamalainagar 608002, Tamil Nadu, India
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 47卷 / 01期
关键词：
m-chloro-perbenzoic acid; spiropiperidinyl-1,2,4-triazolidine-3-thiones; antibacterial activity; antifungal activity; one-pot synthesis; SODIUM-HYDROGEN SULFATE; MICROWAVE IRRADIATION; THIOSEMICARBAZONES; DERIVATIVES; PIPERIDINES; ANTICANCER; EFFICIENT; CATALYST; AGENTS;
D O I：
10.1007/s10593-011-0720-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel approach towards the synthesis of spiropiperidinyl 1,2,4-triazolidine-3-thiones was proposed, exploiting microwave activation coupled with solvent-free reaction conditions. In search for new leads towards potent antimicrobial agents, we tested all the synthesized compounds for their in vitro antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida-6, and Candida-51. Two of the compounds exerted strong in vitro antibacterial activity against B. subtilis and M. luteus, and all the synthesized compounds were potent against the tested fungal strains.
引用
收藏
页码：60 / 66
页数：7
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