SOLVENT-FREE ONE-POT SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF NOVEL SPIROPIPERIDINYL-1,2,4-TRIAZOLIDINE-3-THIONES

被引：7
|
作者：
Kanagarajan, V. [1 ]
Thanusu, J. [1 ]
Ezhilarasi, M. R. [1 ]
Gopalakrishnan, M. [1 ]
机构：
[1] Annamalai Univ, Dept Chem, Synthet Organ Chem Lab, Annamalainagar 608002, Tamil Nadu, India
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 47卷 / 01期
关键词：
m-chloro-perbenzoic acid; spiropiperidinyl-1,2,4-triazolidine-3-thiones; antibacterial activity; antifungal activity; one-pot synthesis; SODIUM-HYDROGEN SULFATE; MICROWAVE IRRADIATION; THIOSEMICARBAZONES; DERIVATIVES; PIPERIDINES; ANTICANCER; EFFICIENT; CATALYST; AGENTS;
D O I：
10.1007/s10593-011-0720-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel approach towards the synthesis of spiropiperidinyl 1,2,4-triazolidine-3-thiones was proposed, exploiting microwave activation coupled with solvent-free reaction conditions. In search for new leads towards potent antimicrobial agents, we tested all the synthesized compounds for their in vitro antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida-6, and Candida-51. Two of the compounds exerted strong in vitro antibacterial activity against B. subtilis and M. luteus, and all the synthesized compounds were potent against the tested fungal strains.
引用
收藏
页码：60 / 66
页数：7
相关论文
共 50 条
  • [1] Solvent-free one-pot synthesis, characterization, antibacterial and antifungal activities of novel spiropiperidinyl-1,2,4-triazolidine-3-thiones
    V. Kanagarajan
    J. Thanusu
    M. R. Ezhilarasi
    M. Gopalakrishnan
    Chemistry of Heterocyclic Compounds, 2011, 47 : 60 - 66
  • [2] Unveiling the catalytic potency of a novel hydrazone-linked covalent organic framework for the highly efficient one-pot synthesis of 1,2,4-triazolidine-3-thiones
    Teli, Pankaj
    Soni, Shivani
    Teli, Sunita
    Agarwal, Shikha
    NANOSCALE ADVANCES, 2024, : 5568 - 5578
  • [3] A convenient solvent-free and one-pot synthesis of 4-hydroxythiazolidine-2-thiones
    Nasiri, Farough
    Zolali, Amin
    Ahmadiazar, Mohammad
    JOURNAL OF SULFUR CHEMISTRY, 2014, 35 (04) : 412 - 417
  • [4] Novel, green and sustainable route for synthesis of 5-aryl-4-phenyl-1,2,4-triazolidine-3-thiones
    Patil, Mayuri
    Mhaldar, Pradeep
    Mahadik, Vrushali
    Pore, Dattaprasad M.
    TETRAHEDRON LETTERS, 2020, 61 (25)
  • [5] Design, 'one-pot' synthesis, characterization, antibacterial and antifungal activities of novel 6-aryl-1,2,4,5-tetrazinan-3-thiones in dry media
    Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India
    J. Sulfur Chem., 2007, 4 (383-392):
  • [6] Novel task-specific ionic liquid for room temperature synthesis of spiro-1,2,4-triazolidine-3-thiones
    Suyog N. Korade
    Jayavant D. Patil
    Dattaprasad M. Pore
    Monatshefte für Chemie - Chemical Monthly, 2016, 147 : 2143 - 2149
  • [7] Novel task-specific ionic liquid for room temperature synthesis of spiro-1,2,4-triazolidine-3-thiones
    Korade, Suyog N.
    Patil, Jayavant D.
    Pore, Dattaprasad M.
    MONATSHEFTE FUR CHEMIE, 2016, 147 (12): : 2143 - 2149
  • [8] Solvent-free one-pot synthesis of 2-pyridone derivatives
    Hossaini, Zinatossadat
    Rostami-Charati, Faramarz
    Hajinasiri, Rahimeh
    Khalilzadeh, Mohammad A.
    CHINESE CHEMICAL LETTERS, 2012, 23 (05) : 512 - 514
  • [9] Solvent-free one-pot synthesis of 2-pyridone derivatives
    Zinatossadat Hossaini
    Faramarz ROstami-Charati
    Rahimeh Hajinasiri
    Mohammad A.Khalilzadeh
    ChineseChemicalLetters, 2012, 23 (05) : 512 - 514
  • [10] Benzyltriphenylphosphonium Chloride: An Efficient Catalyst for One-Pot Synthesis of Dihydropyrimidinones/thiones Under Solvent-Free Conditions
    Alikarami, Mohammad
    Moradi, Ronak
    LETTERS IN ORGANIC CHEMISTRY, 2015, 12 (08) : 560 - 565
12345