Involvement of N-type voltage-activated Ca2+ channels in the release of endogenous noradrenaline from the isolated vascularly perfused rat stomach

被引：7
|
作者：
Yokotani, K [1 ]
Okuma, Y [1 ]
Osumi, Y [1 ]
机构：
[1] Kochi Med Sch, Dept Pharmacol, Nanko Ku, Kochi 7838505, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 78卷 / 01期
关键词：
noradrenaline release; rat stomach; N-type Ca2+ channel;
D O I：
10.1254/jjp.78.75
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We characterized the voltage-activated Ca2+ channels involved in noradrenaline (NA) release from gastric sympathetic neurons using isolated, vascularly perfused rat stomach. The evoked NA release by electrical stimulation of periarterial nerves was abolished by calcium removal from the perfusion medium and by cadmium, omega-Conotoxin GVIA (N-type Ca2+-channel blocker) effectively and omega-conotoxin MVIIC (N/P/Q-type blocker) slightly inhibited the evoked NA, while omega-agatoxin IVA (P-type blocker) had no effect. These results suggest that omega-conotoxin GVIA and omega-conotoxin MVIIC-sensitive N-type Ca2+ channels are involved in NA release from the rat gastric sympathetic nerve terminals.
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页码：75 / 77
页数：3
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