Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones

被引：11
|
作者：
Nozawa-Kumada, Kanako [1 ]
Matsuzawa, Yuta [1 ]
Ono, Kanako [1 ]
Shigeno, Masanori [1 ]
Kondo, Yoshinori [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, 6-3 Aoba, Sendai, Miyagi 9808578, Japan
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 69期
基金：
日本学术振兴会;
关键词：
C-H ACTIVATION; 3+2 ANNULATION; OXIDATION; AMINATION; DERIVATIVES; MOLECULES; KETIMINES; ALKYNES;
D O I：
10.1039/d1cc02870g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the benzylic double C(sp(3))-H functionalization of 2-alkylbenzamides. In this reaction, molecular oxygen was used as both an oxidant for C(sp(3))-H functionalization and an oxygen source. Our method can be extended to diverse benzylic C(sp(3))-H bonds and shows excellent functional group tolerance.
引用
收藏
页码：8604 / 8607
页数：4
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