Tetrasubstituted 1,3-Enynes by Gold-Catalyzed Direct C(sp2)-H Alkynylation of Acceptor-Substituted Enamines

被引：17
|
作者：
Han, Chunyu [1 ]
Tian, Xianhai [1 ]
Zhang, Huili [1 ]
Rominger, Frank [1 ]
Hashmi, A. Stephen K. [1 ,2 ]
机构：
[1] Heidelberg Univ, Organ Chem Inst, D-69120 Heidelberg, Germany
[2] King Abdulaziz Univ, Fac Sci, Chem Dept, Jeddah 21589, Saudi Arabia
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 12期
关键词：
C-H ALKYNYLATION; TERMINAL ALKYNES; BENZIODOXOLE REAGENTS; ACCESS; DIMERIZATION; RUTHENIUM; ACIDS; EBX;
D O I：
10.1021/acs.orglett.1c01486
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp(2))-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance.
引用
收藏
页码：4764 / 4768
页数：5
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