A brief history of the discovery of the mitochondrial unfolded protein response in mammalian cells

被引：9
|
作者：
Hoogenraad, Nick [1 ]
机构：
[1] La Trobe Univ, Melbourne, Vic 3086, Australia
来源：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2017年 / 49卷 / 04期
关键词：
Mitochondria; Unfolded proteins; Stress response; TRANSCRIPTION FACTOR; CHAPERONES; INDUCTION; GENES; PROMOTER; SIGNALS; MATRIX; GENOME;
D O I：
10.1007/s10863-017-9703-2
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Cells have responded to stresses which cause proteins to come out of solution by evolving unfolded protein response mechanisms. In eukaryotic cells there are several such mechanisms covering the whole cell and sub-celllular organelles. This review describes discoveries that describe the unfolded protein response in the matrix compartment of mitochondria (mtUPRR) of mammalian cells.
引用
收藏
页码：293 / 295
页数：3
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