INHIBITION OF THE PURINERGIC RECEPTOR P2X7, ATTENUATES CASPASE-1 ACTIVATION AND IL-1B RELEASE IN RAT MIXED GLIAL CULTURES TREATED WITH ADENOSINE TRIPHOSPHATE

被引：0
|
作者：
Murphy, N. [1 ]
Lynch, M. A. [1 ]
机构：
[1] Univ Dublin Trinity Coll, Dept Physiol, Inst Neurosci, Dublin 2, Ireland
来源：
IRISH JOURNAL OF MEDICAL SCIENCE | 2010年 / 179卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：S128 / S128
页数：1
相关论文
共 50 条
  • [21] P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1β release
    Verhoef, PA
    Estacion, M
    Schilling, W
    Dubyak, GR
    JOURNAL OF IMMUNOLOGY, 2003, 170 (11): : 5728 - 5738
  • [22] Activation of P2X7 receptor leads to maturation and release of IL-1beta by LPS-primed Schwann cells
    Colomar, A
    Combe, C
    Amédée, T
    Parnet, P
    GLIA, 2002, : S60 - S60
  • [23] In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain
    Mingam, Rozenn
    De Smedt, Veronique
    Amedee, Thierry
    Bluthe, Rose-Marie
    Kelley, Keith W.
    Dantzer, Robert
    Laye, Sophie
    BRAIN BEHAVIOR AND IMMUNITY, 2008, 22 (02) : 234 - 244
  • [24] P2X7 receptor differentially couples to distinct release pathways for IL-1β in mouse macrophage
    Pelegrin, Pablo
    Barroso-Gutierrez, Consuelo
    Surprenant, Annmarie
    JOURNAL OF IMMUNOLOGY, 2008, 180 (11): : 7147 - 7157
  • [25] P2X7 receptor inhibition alleviates amphetamine induced hyperactivity independently from IL-1β
    Goloncser, Flora
    Baranyi, Maria
    Tod, Pal
    Maacz, Fruzsina
    Sperlagh, Beata
    BRITISH JOURNAL OF PHARMACOLOGY, 2023, 180 : 978 - 979
  • [26] P2X7 Receptor and Caspase 1 Activation Are Central to Airway Inflammation Observed after Exposure to Tobacco Smoke
    Eltom, Suffwan
    Stevenson, Christopher S.
    Rastrick, Joseph
    Dale, Nicole
    Raemdonck, Kristof
    Wong, Sissie
    Catley, Matthew C.
    Belvisi, Maria G.
    Birrell, Mark A.
    PLOS ONE, 2011, 6 (09):
  • [27] Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism
    Brough, D
    Le Feuvre, RA
    Iwakura, Y
    Rothwell, NJ
    MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 19 (02) : 272 - 280
  • [28] Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle
    Kojima, Shuji
    Negishi, Yusuke
    Tsukimoto, Mitsutoshi
    Takenouchi, Takato
    Kitani, Hiroshi
    Takeda, Ken
    TOXICOLOGY, 2014, 321 : 13 - 20
  • [29] P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway
    Zhao, Jijun
    Wang, Hongyue
    Dai, Chao
    Wang, Hongyang
    Zhang, Hui
    Huang, Yuefang
    Wang, Shuang
    Gaskin, Felicia
    Yang, Niansheng
    Fu, Shu Man
    ARTHRITIS AND RHEUMATISM, 2013, 65 (12): : 3176 - 3185
  • [30] Pannexin-1/P2X7 Purinergic Receptor Channels Mediate the Release of Cardioprotectants Induced by Ischemic Pre- and Postconditioning
    Vessey, Donald A.
    Li, Luyi
    Kelley, Michael
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2010, 15 (02) : 190 - 195
12345