Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex

被引：16

作者：

Iturriaga, Rodrigo ^{[1
,2
]}

Del Rio, Rodrigo ^{[2
,3
,4
]}

Alcayaga, Julio ^{[5
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Lab Neurobiol, Santiago, Chile

[2] Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile

[3] Pontificia Univ Catolica Chile, Dept Physiol, Lab Cardioresp Control, Santiago, Chile

[4] Pontificia Univ Catolica Chile, Ctr Envejecimiento & Regenerac CARE, Santiago, Chile

[5] Univ Chile, Fac Ciencias, Lab Fisiol Celular, Santiago, Chile

来源：

PHYSIOLOGY | 2022年 / 37卷 / 03期

关键词：

carotid body; inflammation; intermittent and sustained hypoxia; obstructive sleep apnea; oxidative stress; OBSTRUCTIVE SLEEP-APNEA; RECEPTOR-TYPE-I; INTERMITTENT HYPOXIA; VAGUS NERVE; SEX-DIFFERENCES; GLOMUS CELLS; CARDIORESPIRATORY ALTERATIONS; ARTERIAL CHEMORECEPTORS; CARDIOVASCULAR-DISEASE; VAGAL PARAGANGLIA;

D O I：

10.1152/physiol.00031.2021

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Emergent evidence indicates that the carotid body (CB) chemoreceptor may sense systemic inflammatory molecules and is an afferent arm of the anti-inflammatory reflex. Moreover, a proinflammatory milieu within the CB is involved in the enhanced CB chemosensory responsiveness to oxygen following sustained and intermittent hypoxia. In this review, we focus on the physiopathological participation of CBs in inflammatory diseases, such as sepsis and intermittent hypoxia.

引用

页码：128 / 140

页数：13

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