Kruppel-like Factor 4 (KLF4) Suppresses T-Cell Acute Lymphoblastic Leukemia By Inhibiting Expression of MAP2K7 and Expansion of Leukemia Initiating Cells

被引：0
|
作者：
Shen, Ye [1 ]
Park, Chun Shik [1 ]
Suppipat, Koramit [2 ]
Yamada, Takeshi [1 ]
Mistretta, Toni-Ann [3 ]
Lacorazza, Daniel [1 ]
机构：
[1] Texas Childrens Hosp, Baylor Coll Med, Houston, TX 77030 USA
[2] Texas Childrens Hosp, Baylor Coll Med, Texas Childrens Canc & Hematol Ctr, Houston, TX 77030 USA
[3] Texas Childrens Hosp, Houston, TX 77030 USA
来源：
BLOOD | 2014年 / 124卷 / 21期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [31] KLF9 promotes autophagy and apoptosis in T-cell acute lymphoblastic leukemia cells by inhibiting AKT/mTOR signaling pathway
    Jie Zhao
    Shaolong He
    Chenhuan Xiang
    Shaoli Zhang
    Xinyue Chen
    Xinyi Lu
    Qiong Yao
    Liping Yang
    Liangming Ma
    Weiwei Tian
    Molecular & Cellular Toxicology, 2023, 19 : 531 - 538
  • [32] The Kruppel-like Factor 4 Sustains a Leukemic Gene Expression Profile in MLL-AF9-Driven Acute Myeloid Leukemia
    Lewis, Andrew
    Bridges, Cory Seth
    Moorshead, David
    Du, Wa
    Zorman, Barry
    Sumazin, Pavel
    Puppi, Monica
    Lacorazza, H. Daniel
    BLOOD, 2021, 138
  • [33] The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells
    Wang, H
    Yang, L
    Jamaluddin, MS
    Boyd, DD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (21) : 22674 - 22683
  • [34] Over-expression of gut-enriched Kruppel-Like factor (GKLF or KLF4) in the human colon cancer cell line RKO leads to reduced tumorigenicity
    Deng, DYT
    Chen, XM
    Dang, LH
    Yang, VW
    GASTROENTEROLOGY, 2002, 122 (04) : A97 - A98
  • [35] NKG2D-CAR MEMORY T CELLS TARGET PEDIATRIC T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA IN VITRO AND IN VIVO BUT FAIL TO ELIMINATE LEUKEMIA INITIATING CELLS
    Ibanez-Navarro, M.
    Fernandez, A. F.
    Escudero, A.
    Esteso, G.
    Campos-Silva, C.
    Navarro-Aguadero, M. A.
    Leivas, A.
    Ruz-Caracuel, B.
    Rodriguez-Antolin, C.
    Ortiz, A.
    Navarro-Zapata, A.
    Mestre-Duran, C.
    Balaguer-Perez, M.
    Ferreras, C.
    Martinez-Lopez, J.
    Vales-Gomez, M.
    Perez-Martinez, A.
    Fernandez, L.
    HUMAN GENE THERAPY, 2023, 34 (21-22) : A9 - A10
  • [36] NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and in vivo but fail to eliminate leukemia initiating cells
    Ibanez-Navarro, Marta
    Fernandez, Adrian
    Escudero, Adela
    Esteso, Gloria
    Campos-Silva, Carmen
    Navarro-Aguadero, Miguel Angel
    Leivas, Alejandra
    Caracuel, Beatriz Ruz
    Rodriguez-Antolin, Carlos
    Ortiz, Alejandra
    Navarro-Zapata, Alfonso
    Mestre-Duran, Carmen
    Izquierdo, Manuel
    Balaguer-Perez, Maria
    Ferreras, Cristina
    Martinez-Lopez, Joaquin
    Vales-Gomez, Mar
    Perez-Martinez, Antonio
    Fernandez, Lucia
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [37] Kruppel-Like Factor 4 (Klf4) Is a Stat3-Smad2 Regulator in ATII Cells Determining ATII Cell Fate During Lung Development and Hyperoxia-Induced Lung Injury
    Mohr, J.
    Koch, M.
    Danopoulos, S.
    Ebert, L.
    Oikonomou, N.
    Vohlen, C.
    Hirani, D. V.
    Al Alam, D.
    Schermer, B.
    Doetsch, J.
    Alcazar, M. Alejandre
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [38] Plumbagin exerts an immunosuppressive effect on human T-cell acute lymphoblastic leukemia MOLT-4 cells
    Bae, Kyoung Jun
    Lee, Yura
    Kim, Soon Ae
    Kim, Jiyeon
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 473 (01) : 272 - 277
  • [39] Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Kruppel-like factor 4-dihydropyrimidinase-like 2A (KLF4-DPYSL2A) axis
    Noura, Mina
    Morita, Ken
    Kiyose, Hiroki
    Okuno, Yukiko
    Matsuo, Hidemasa
    Koyama, Asami
    Nishinaka-Arai, Yoko
    Kamikubo, Yasuhiko
    Adachi, Souichi
    BRITISH JOURNAL OF HAEMATOLOGY, 2021, 194 (03) : 598 - 603
  • [40] Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling
    Cardoso, B. A.
    Martins, L. R.
    Santos, C. I.
    Nadler, L. M.
    Boussiotis, V. A.
    Cardoso, A. A.
    Barata, J. T.
    LEUKEMIA, 2009, 23 (01) : 206 - +
12345