High expression of glycosphingolipids involved in procoagulant activity of cancer cells

被引：0
|
作者：
Suzuki, M
Ando, O
Ohta, T
Inufusa, H
Adachi, T
Yasutomi, M
Kurimoto, M
机构：
[1] Hayashibara Biochem Labs Inc, Fujisaki Cell Ctr, Okayama 7028006, Japan
[2] Kinki Univ, Sch Med, Dept Surg 1, Osakasayama 5898511, Japan
[3] Hayashibara Biochem Labs Inc, Fujisaki Inst, Okayama 7028006, Japan
来源：
ONCOLOGY REPORTS | 1999年 / 6卷 / 01期
关键词：
sialyl Lewis x; sialyl Lewis a; procoagulant activity;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To investigate the involvement of tumor-associated antigens such as sLe(a) and sLe(x), as well as Le(y) glycosphingolipid in the procoagulant activity of cancer cells, we examined the relationship between the inhibitory effect of anti-sLe(a) or anti-sLe(x) antibodies on the procoagulant activity of cancer cells, and cell surface expression of sLe(a) and sLe(x) antigens. We observed that the procoagulant activity of cancer cells which highly expressed sLe(a) or sLe(x) antigens (expression rate >70%) was significantly inhibited by the relevant antibodies. These data suggested that not only Ley but also sLe(a) and sLe(x) antigens play an important role in coagulation induced by various cancer cells.
引用
收藏
页码：113 / 115
页数：3
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