6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand

被引：4
|
作者：
Ramunno, A
Dukat, M
Lee, M
Young, R
El-Zahabi, M
Damaj, MI
Martin, B
Glennon, RA
机构：
[1] Virginia Commonwealth Univ, Dept Med Chem, Sch Pharm, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Sch Med, Richmond, VA 23298 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 13期
关键词：
nACh receptors; antagonist;
D O I：
10.1016/j.bmcl.2005.04.072
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
6-(2-Phenylethyl)nicotine (1b; K-i = 15 nM) was unexpectedly found to bind at alpha 4 beta 2 nicotinic cholinergic (nACh) receptors. Although this compound failed to produce nicotine-like agonist action in several functional assays, 1b antagonized the antinociceptive effects of nicotine (mouse tail-flick assay) in a dose-dependent fashion when administered via an intrathecal route. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3237 / 3240
页数：4
相关论文
共 50 条
  • [21] r-bPiDI, an α6β2*Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement
    Beckmann, Joshua S.
    Meyer, Andrew C.
    Pivavarchyk, M.
    Horton, David B.
    Zheng, Guangrong
    Smith, Andrew M.
    Wooters, Thomas E.
    McIntosh, J. Michael
    Crooks, Peter A.
    Bardo, Michael T.
    Dwoskin, Linda P.
    NEUROCHEMICAL RESEARCH, 2015, 40 (10) : 2121 - 2130
  • [22] r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement
    Joshua S. Beckmann
    Andrew C. Meyer
    M. Pivavarchyk
    David B. Horton
    Guangrong Zheng
    Andrew M. Smith
    Thomas E. Wooters
    J. Michael McIntosh
    Peter A. Crooks
    Michael T. Bardo
    Linda P. Dwoskin
    Neurochemical Research, 2015, 40 : 2121 - 2130
  • [23] Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine
    Gozen, Oguz
    Nesil, Tanseli
    Kanit, Lutfiye
    Koylu, Ersin O.
    Pogun, Sakire
    AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, 2016, 42 (05): : 556 - 566
  • [24] Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos
    Zhao, Yang-Mei
    Yang, Li
    Kong, Fan-Dong
    Dong, Wen-Hua
    Li, Wei
    Chen, Hui-Qin
    Wang, Hao
    Cai, Cai-Hong
    Gai, Cui-Juan
    Mei, Wen-Li
    Dai, Hao-Fu
    NATURAL PRODUCT RESEARCH, 2021, 35 (14) : 2295 - 2302
  • [25] 4-Methyl-N-(2-phenylethyl)-2-propyl-1H-benzimidazole-6-carboxamide
    Wang, Jin-Liang
    Yu, Wei-Fa
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O2824 - +
  • [26] Nicotine enhances intracellular nicotinic receptor maturation: A novel mechanism of neural plasticity?
    Corringer, PJ
    Sallette, J
    Changeux, JP
    JOURNAL OF PHYSIOLOGY-PARIS, 2006, 99 (2-3) : 162 - 171
  • [27] SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SUBSTITUTED N-ACETYL-MERCAPTOPROPIONYL-6-(2-PHENYLETHYL) PIPECOLIC ACIDS
    MASTAFANOVA, LI
    ISAKOVICH, IP
    SHVARTS, GY
    FAERMARK, IF
    ANISIMOVA, OS
    TURCHIN, KF
    SHEINKER, YN
    MASHKOVSKY, MD
    YAKHONTOV, LN
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1988, 22 (03): : 294 - 302
  • [28] α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice
    You, Shen
    Li, Xiaodan
    Xiong, Jian
    Zhu, Xiaoyu
    Zhangsun, Dongting
    Zhu, Xiaopeng
    Luo, Sulan
    MARINE DRUGS, 2019, 17 (09)
  • [29] A Novel Structural Landscape for Ligand Binding to the α7 Nicotinic Acetylcholine Receptor
    Camacho-Bustamante, Gisela Andrea
    Kaczanowska, Kasia
    Harel, Michal
    Cornejo-Bravo, Jose
    Taylor, Palmer
    FASEB JOURNAL, 2016, 30
  • [30] Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats
    Chen, H
    Parker, SL
    Matta, SG
    Sharp, BM
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (02) : 380 - 388
12345