Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research

被引：473
|
作者：
Krafft, MP [1 ]
机构：
[1] Inst Charles Sadron, F-67083 Strasbourg, France
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 47卷 / 2-3期
关键词：
D O I：
10.1016/S0169-409X(01)00107-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The specific properties of fluorocarbons, exceptional chemical and biological inertness, high gas-dissolving capacity, low surface tension, excellent spreading characteristics and high fluidity, have triggered numerous applications of these compounds in oxygen delivery. An injectable emulsion of fluorocarbon-in-water destined to deliver oxygen to tissues at risk of hypoxia has now completed Phase III clinical trials in Europe. A neat fluorocarbon is currently investigated in Phase II for treatment of acute respiratory failure by liquid ventilation. Fluorinated lipids and fluorinated surfactants can be used to elaborate and stabilize various colloidal systems, including different types of emulsions, vesicles and tubules, that also show promise for controlled release drug delivery. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：209 / 228
页数：20
相关论文
共 50 条
  • [31] Miniaturized Drug Delivery System for Biomedical Applications
    Moussi, Khalil
    AlDajani, Mohammed
    Kosel, Jurgen
    2019 14TH ANNUAL IEEE INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS (IEEE-NEMS 2019), 2019, : 97 - 100
  • [32] Emulsions stabilized with dextran-based amphiphiles for drug delivery applications
    Pinzon, PA
    McElearney, K
    Correia, R
    Durand, A
    Léonard, M
    Camesano, TA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U1112 - U1113
  • [33] Bioresorbable polyelectrolyte amphiphiles as nanosized carriers for lipophilic drug solubilization and delivery
    Domurado, Dominique
    Vert, Michel
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2007, 18 (03) : 287 - 301
  • [34] Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery
    Alea-Reyes, Maria E.
    Gonzalez, Asensio
    Calpena, Ana C.
    Ramos-Lopez, David
    de lapuente, Joaquin
    Perez-Garcia, Lluisa
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2017, 502 : 172 - 183
  • [35] Fluorinated covalent organic frameworks for efficient drug delivery
    Ma, Baiwei
    Xu, Yimeng
    Hu, Fujia
    Zhai, Lipeng
    Huang, Yongyu
    Qiao, Huijie
    Xiong, Jiabin
    Yang, Dehong
    Ni, Zhihui
    Zheng, Xiaofei
    Mi, Liwei
    RSC ADVANCES, 2022, 12 (48) : 31276 - 31281
  • [36] Drug delivery research
    Nature Reviews Drug Discovery, 2009, 8 (1) : 87 - 87
  • [37] A review of polymeric biomaterials research for tissue engineering and drug delivery applications at the Centre for Biomedical and Biomaterials Research, Mauritius
    Bhaw-Luximon, Archana
    Jeetah, Roubeena
    Goonoo, Nowsheen
    Veeren, Anisha
    Jugdawa, Yeshma
    Jhurry, Dhanjay
    AFRICAN JOURNAL OF SCIENCE TECHNOLOGY INNOVATION & DEVELOPMENT, 2014, 6 (02): : 145 - 157
  • [38] Biomedical research: Drug hunters wanted
    Perkel J.M.
    Nature, 2015, 524 (7564) : 257 - 258
  • [39] Biomedical and health delivery systems research at NSF
    Rardin, R
    MEDICAL PHYSICS, 2002, 29 (06) : 1362 - 1362
  • [40] Evolution of drug-eluting biomedical implants for sustained drug delivery
    Quarterman, Juliana C.
    Geary, Sean M.
    Salem, Aliasger K.
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021, 159 : 21 - 35
12345