A convenient selective N-alkylation of 4-oxo-1,4-dihydro-2-quinoline carboxylic acid

被引：0
|
作者：
Edmont, D [1 ]
Chenault, J [1 ]
机构：
[1] Univ Orleans, Inst Chim Organ & Analyt, F-45067 Orleans 2, France
来源：
SYNLETT | 2001年 / 06期
关键词：
N-alkylation; heterocycles; quinolines; ring-opening; intramolecular cyclization;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The selective N-alkylation of 4-oxo-1,4-dihydro-2-quinoline carboxylic acid has been achieved from 1,2-dihydro[1,4]oxazino[4,3-a]quinoline-4,6-dione by the 2-morpholinone ring opening. In the same time, we have developed a new methodology to obtain the 1,2-dihydro[ 1,4]oxazino[4,3-a]quinoline-4,6-dione that involves an intramolecular cyclization of the 2-choroethyl 6-fluoro-4-oxo-1,4-dihydro-2-quinoline carboxylate.
引用
收藏
页码：833 / 835
页数：3
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