What are the structural features of the active site that define binuclear copper proteins function?

被引：3

作者：

Bubacco, L ^{[1
]}

van Gastel, M

Benfatto, M

Tepper, AWJW

Canters, GW

机构：

[1] Univ Padua, Dipartimento Biol, Padua, Italy

[2] Leiden Univ, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands

[3] Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy

来源：

MICRON | 2004年 / 35卷 / 1-2期

关键词：

binuclear; copper; tyrosinase; hemocyanin; active site;

D O I：

10.1016/j.micron.2003.10.046

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

The structural basis that define the physiological functions of binuclear copper enzymes is discussed in the frame of the data generated by a broad spectroscopic approach, spanning from paramagnetic NMR and pulsed EPR to x-ray absorption spectroscopies. The structural features discussed for the different oxidation and ligation states accessible to a binuclear copper sites are the coordination geometry for the first and second shell, the metal-metal distance and the role of the bridging exogenous ligand(s). A structural model will be presented to rationalize both the differentiation in function within the protein families and the reaction mechanism of those proteins that are enzymatically active. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：143 / 145

页数：3

共 50 条

[21] RESONANCE RAMAN STUDIES OF THE COUPLED BINUCLEAR COPPER ACTIVE-SITE IN MET AZIDE HEMOCYANIN
PATE, JE
THAMANN, TJ
SOLOMON, EI
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 1986, 42 (2-3): : 313 - 318
[22] Ultrafast studies of active site dynamics in blue copper proteins.
Book, LD
Scherer, NF
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U778 - U778
[23] How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript
Rubtsova, Maria
Dontsova, Olga
BIOMEDICINES, 2022, 10 (07)
[24] Copper ligand influences in synthetic model reactivity studies of the cytochrome c oxidase binuclear active site
Karlin, KD
Kim, E
Ghiladi, RA
Helton, ME
Shearer, J
Lu, S
Huang, H
Moenne-Loccoz, P
JOURNAL OF INORGANIC BIOCHEMISTRY, 2003, 96 (01) : 163 - 163
[25] MODELING STUDIES OF THE IRON COPPER BINUCLEAR ACTIVE-SITE OF BOVINE CYTOCHROME-C OXIDASE
WILSON, LJ
CHUNPLANG, V
LEMKE, BK
MERRILL, CL
SAXTON, RJ
WATSON, ML
INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1983, 79 (1-6): : 107 - 109
[26] Catecholate adducts of binuclear copper complexes modelling the type 3 copper active site - Spectroscopic characterization and relevance to the tyrosinase reaction
Plenge, T
Dillinger, R
Santagostini, L
Casella, L
Tuczek, F
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 2003, 629 (12-13): : 2258 - 2265
[27] STRUCTURE, SPECTRA AND FUNCTION OF THE ACTIVE-SITE OF HEME-PROTEINS
LOEW, GH
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1983, 186 (AUG): : 3 - PHYS
[28] Metallothioneins: Zinc, cadmium, mercury, and copper thiolates and selenolates mimicking protein active site features - Structural aspects and biological implications
Henkel, G
Krebs, B
CHEMICAL REVIEWS, 2004, 104 (02) : 801 - 824
[29] Oxygen activation by the noncoupled binuclear copper site in peptidylglycine α-hydroxylating monooxygenase.: Reaction mechanism and role of the noncoupled nature of the active site
Chen, P
Solomon, EI
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (15) : 4991 - 5000
[30] BIOLOGICAL ANALOGS - A STRUCTURAL MODEL FOR THE BINDING-SITE OF BLUE COPPER PROTEINS
WHELAN, J
BOSNICH, B
INORGANIC CHEMISTRY, 1986, 25 (20) : 3671 - 3675

← 1 2 3 4 5 →