Anterior Mediastinal Lymph Nodes in Chemically Induced Breast Cancer

被引：0
|
作者：
Kazakov, O. V. [1 ]
Kabakov, A. V. [1 ]
Poveshchenko, A. F. [1 ]
Raiter, T. V. [1 ]
Strunkin, D. N. [1 ]
Ishchenko, I. Yu. [1 ]
Lykov, A. P. [1 ]
Michurina, S. V. [1 ]
Konenkov, V. I. [1 ]
机构：
[1] Res Inst Expt & Clin Lymphol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 164卷 / 02期
关键词：
chemically induced breast cancer; female Wistar rats; anterior mediastinal lymph nodes; morphometry;
D O I：
10.1007/s10517-017-3954-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The anterior mediastinal lymph nodes were analyzed morphometrically in rats with chemically provoked breast cancer. Rats with untreated breast cancer and animals receiving chemotherapy demonstrated decreased volumes of paracortical region and lymphoid nodules with the germinal centers accompanied by extended medullary thymic substance. Resection of largest focus of breast tumor improved the filtration barrier potential of anterior mediastinal lymph nodes, up-regulated the proliferative activity of lymphoid cells in T-cell zones, and down-regulated proliferation of plasmatic cells.
引用
收藏
页码：186 / 190
页数：5
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