One-Pot Synthesis of an 125I-Labeled Trifunctional Reagent for Multiscale Imaging with Optical and Nuclear Techniques

被引：34

作者：

Yan, Ran ^{[1
,2
]}

El-Emir, Ethaar ^{[3
]}

Rajkumar, Vineeth ^{[3
]}

Robson, Mathew ^{[3
]}

Jathoul, Amit P. ^{[3
]}

Pedley, R. Barbara ^{[3
]}

Arstad, Erik ^{[1
,2
]}

机构：

[1] UCL, Inst Nucl Med, London NW1 2BU, England

[2] UCL, Dept Chem, London NW1 2BU, England

[3] UCL, UCL Canc Inst, London WC1E 6BT, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 30期

基金：

英国工程与自然科学研究理事会;

关键词：

click chemistry; fluorescence; imaging agents; iodotriazoles; radiochemistry; ANTIBODY; PROBE; RADIOIMMUNOTHERAPY; CARCINOMAS; EMISSION; AZIDE; PET;

D O I：

10.1002/anie.201102072

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and rapid CuII-mediated three-component "click reaction" allows one-pot assembly of dual optical and nuclear labeling reagents. Proof-of-concept imaging studies demonstrate that the distribution of the dual-labeled antibody A5B7 can be interrogated from the cellular to the macroscopic level using a combination of optical and nuclear imaging techniques. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6793 / 6795

页数：3