One-Pot Synthesis of an 125I-Labeled Trifunctional Reagent for Multiscale Imaging with Optical and Nuclear Techniques

被引：34
|
作者：
Yan, Ran [1 ,2 ]
El-Emir, Ethaar [3 ]
Rajkumar, Vineeth [3 ]
Robson, Mathew [3 ]
Jathoul, Amit P. [3 ]
Pedley, R. Barbara [3 ]
Arstad, Erik [1 ,2 ]
机构：
[1] UCL, Inst Nucl Med, London NW1 2BU, England
[2] UCL, Dept Chem, London NW1 2BU, England
[3] UCL, UCL Canc Inst, London WC1E 6BT, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 30期
基金：
英国工程与自然科学研究理事会;
关键词：
click chemistry; fluorescence; imaging agents; iodotriazoles; radiochemistry; ANTIBODY; PROBE; RADIOIMMUNOTHERAPY; CARCINOMAS; EMISSION; AZIDE; PET;
D O I：
10.1002/anie.201102072
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient and rapid CuII-mediated three-component "click reaction" allows one-pot assembly of dual optical and nuclear labeling reagents. Proof-of-concept imaging studies demonstrate that the distribution of the dual-labeled antibody A5B7 can be interrogated from the cellular to the macroscopic level using a combination of optical and nuclear imaging techniques. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：6793 / 6795
页数：3
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