A Bacteria-based Experimental Platform to Test Parameters Raised by Mathematical Models on Population Dynamics

Bacterial populations are current models to assay biological effects of a number of different treatments on the basis of a high-number statistics. One typical bacterial inoculum grows at doubling rates as fast as some 30min per generation, reaching up to similar to 109 cells per ml of medium in a few hours. Given the features of such experimental protocol, it is easy to test the impact of environmental modifications during bacteria growth, by scoring doubling rates time, final cell concentration, oxygen consumption, mutagenesis rate:, cell viability under different selective pressures, etc. The drawing of a actual dose-response or kinetic curves can feed parameters on a given mathematical model on population dynamics by weighting each equation term. The purpose of this talk is to present experimental schemes with bacterial populations so as to serve as parallel two-hands testing of different mathematical models on populations dynamics.