Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation pathway in rat livers

被引：13
|
作者：
Fukuda, Itsuko [1 ]
Nishiumi, Shin [2 ]
Mukai, Rie [2 ]
Yoshida, Ken-ichi [2 ]
Ashida, Hitoshi [2 ]
机构：
[1] Kobe Univ, Grad Sch Agr Sci, Res Ctr Food Safety & Secur, Kobe, Hyogo 6578501, Japan
[2] Kobe Univ, Grad Sch Agr Sci, Dept Agrobiosci, Div Appl Chem Biosci, Kobe, Hyogo 6578501, Japan
来源：
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2015年 / 66卷 / 03期
关键词：
Aryl hydrocarbon receptor; catechin; cytochrome P450 1As; tea; ACCELERATES DIOXIN EXCRETION; DRUG-METABOLIZING-ENZYMES; LIQUID-CHROMATOGRAPHY; ETHANOLIC EXTRACTS; OXIDATIVE STRESS; TRANSFORMATION; GREEN; EXPRESSION; GENE; POLYPHENOLS;
D O I：
10.3109/09637486.2014.992007
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). The suppressive effects of brewed green tea and black tea on 3-methylcholanthrene (MC)-induced AhR activation and its downstream events were examined in the liver of rats. Ad-libitum drinking of green tea and black tea suppressed MC-induced AhR activation and elevation of ethoxyresorufin O-deethylase activity in the liver, whereas the teas themselves did not induce them. Tea showed a suppressive fashion on the expression of cytochrome P450 1A1 (CYP1A1). Tea suppressed the AhR activation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ex vivo. A part of catechins and theaflavins was present in plasma and liver as conjugated and intact forms. The results of this study suggested that active component(s) of tea are incorporated in the liver and suppress the activity of CYP1As through the AhR activation pathway.
引用
收藏
页码：300 / 307
页数：8
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