Preclinical Imaging of siRNA Delivery

被引：1
|
作者：
Fletcher, Nicholas [1 ,2 ]
Ardana, Aditya [1 ,2 ]
Thurecht, Kristofer J. [1 ,2 ,3 ]
机构：
[1] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia
[3] ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic, Australia
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2016年 / 69卷 / 10期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
NONVIRAL VECTOR; VIVO; CANCER; NANOPARTICLES; MICE; PHARMACOKINETICS; BIODISTRIBUTION; KNOCKING; POLYMERS; THERAPY;
D O I：
10.1071/CH16079
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Small interfering RNA (siRNA) is emerging as a class of therapeutic with extremely high potential, particularly in the field of oncology. Despite this growing interest, further understanding of how siRNA behaves in vivo is still required before significant uptake into clinical application. To this end, many molecular imaging modalities have been utilised to gain a better understanding of the biodistribution and pharmacokinetics of administered siRNA and delivery vehicles. This highlight aims to provide an overview of the current state of the field for preclinical imaging of siRNA delivery.
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页码：1073 / 1077
页数：5
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